An epigenetic marker panel for screening and prognostic prediction of ovarian cancer

Her Young Su, Hung Cheng Lai, Ya Wen Lin, Yu Ching Chou, Chin Yu Liu, Mu Hsien Yu

研究成果: 雜誌貢獻文章同行評審

123 引文 斯高帕斯(Scopus)

摘要

Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum of affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction of 7 genes, which included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRPI, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1) and LIM homeobox transcription factor 1, alpha (LMX1A) in primary tumor samples from 126 patients with ovarian cancer, 75 with a benign tumor and 14 with borderline malignancy of an ovarian tumor, and in the serum from 26 patients with ovarian cancer and 20 with a benign tumor. Six of 7 genes had higher methylation rates in patients with ovarian cancer than in borderline malignancy or benign tumor (p

原文英語
頁(從 - 到)387-393
頁數7
期刊International Journal of Cancer
124
發行號2
DOIs
出版狀態已發佈 - 1月 15 2009
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科
  • 醫藥 (全部)

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