An appendectomy increases the risk of rheumatoid arthritis: A five-year follow-up study

Ya Mei Tzeng, Li Ting Kao, Senyeong Kao, Herng Ching Lin, Ming Chieh Tsai, Cha Ze Lee

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Many studies have reported a possible association of an appendectomy with rheumatoid arthritis (RA). However, findings of the relationship between an appendectomy and RA remain inconsistent. Furthermore, all such studies were conducted in Western societies, and relevant studies on the relationship between an appendectomy and RA in Asian countries are still lacking. In this study, we investigated the relationship between an appendectomy and the subsequent risk of RA using a population-based dataset. We retrieved data for this retrospective cohort study from the Taiwan "Longitudinal Health Insurance Database 2005". We included 4,294 subjects who underwent an appendectomy in the study cohort and 12,882 matched subjects in the comparison cohort. We individually tracked each subject for a 5-year period from their index date to identify those who developed RA. A stratified Cox proportional hazard regression was performed to calculate the hazard ratio (HR) and its corresponding 95% confidence interval (CI) for the subsequent development of RA during the 5-year follow-up period between subjects who underwent an appendectomy and comparison subjects. Of the sampled subjects, 93 (0.54%) received a diagnosis of RA during the 5-year follow-up period: 33 from the study cohort (0.77% of subjects who underwent an appendectomy) and 60 from the comparison cohort (0.47% of comparison subjects) (p
原文英語
文章編號e0126816
期刊PLoS One
10
發行號5
DOIs
出版狀態已發佈 - 五月 13 2015

指紋

Appendectomy
rheumatoid arthritis
Rheumatoid Arthritis
Hazards
Health insurance
cohort studies
Cohort Studies
health insurance
Health Insurance
Taiwan
confidence interval
Retrospective Studies
Databases
Confidence Intervals
Population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

An appendectomy increases the risk of rheumatoid arthritis : A five-year follow-up study. / Tzeng, Ya Mei; Kao, Li Ting; Kao, Senyeong; Lin, Herng Ching; Tsai, Ming Chieh; Lee, Cha Ze.

於: PLoS One, 卷 10, 編號 5, e0126816, 13.05.2015.

研究成果: 雜誌貢獻文章

Tzeng, Ya Mei ; Kao, Li Ting ; Kao, Senyeong ; Lin, Herng Ching ; Tsai, Ming Chieh ; Lee, Cha Ze. / An appendectomy increases the risk of rheumatoid arthritis : A five-year follow-up study. 於: PLoS One. 2015 ; 卷 10, 編號 5.
@article{36f8f029f8514b8191c65b01cfbccb48,
title = "An appendectomy increases the risk of rheumatoid arthritis: A five-year follow-up study",
abstract = "Many studies have reported a possible association of an appendectomy with rheumatoid arthritis (RA). However, findings of the relationship between an appendectomy and RA remain inconsistent. Furthermore, all such studies were conducted in Western societies, and relevant studies on the relationship between an appendectomy and RA in Asian countries are still lacking. In this study, we investigated the relationship between an appendectomy and the subsequent risk of RA using a population-based dataset. We retrieved data for this retrospective cohort study from the Taiwan {"}Longitudinal Health Insurance Database 2005{"}. We included 4,294 subjects who underwent an appendectomy in the study cohort and 12,882 matched subjects in the comparison cohort. We individually tracked each subject for a 5-year period from their index date to identify those who developed RA. A stratified Cox proportional hazard regression was performed to calculate the hazard ratio (HR) and its corresponding 95{\%} confidence interval (CI) for the subsequent development of RA during the 5-year follow-up period between subjects who underwent an appendectomy and comparison subjects. Of the sampled subjects, 93 (0.54{\%}) received a diagnosis of RA during the 5-year follow-up period: 33 from the study cohort (0.77{\%} of subjects who underwent an appendectomy) and 60 from the comparison cohort (0.47{\%} of comparison subjects) (p",
author = "Tzeng, {Ya Mei} and Kao, {Li Ting} and Senyeong Kao and Lin, {Herng Ching} and Tsai, {Ming Chieh} and Lee, {Cha Ze}",
year = "2015",
month = "5",
day = "13",
doi = "10.1371/journal.pone.0126816",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - An appendectomy increases the risk of rheumatoid arthritis

T2 - A five-year follow-up study

AU - Tzeng, Ya Mei

AU - Kao, Li Ting

AU - Kao, Senyeong

AU - Lin, Herng Ching

AU - Tsai, Ming Chieh

AU - Lee, Cha Ze

PY - 2015/5/13

Y1 - 2015/5/13

N2 - Many studies have reported a possible association of an appendectomy with rheumatoid arthritis (RA). However, findings of the relationship between an appendectomy and RA remain inconsistent. Furthermore, all such studies were conducted in Western societies, and relevant studies on the relationship between an appendectomy and RA in Asian countries are still lacking. In this study, we investigated the relationship between an appendectomy and the subsequent risk of RA using a population-based dataset. We retrieved data for this retrospective cohort study from the Taiwan "Longitudinal Health Insurance Database 2005". We included 4,294 subjects who underwent an appendectomy in the study cohort and 12,882 matched subjects in the comparison cohort. We individually tracked each subject for a 5-year period from their index date to identify those who developed RA. A stratified Cox proportional hazard regression was performed to calculate the hazard ratio (HR) and its corresponding 95% confidence interval (CI) for the subsequent development of RA during the 5-year follow-up period between subjects who underwent an appendectomy and comparison subjects. Of the sampled subjects, 93 (0.54%) received a diagnosis of RA during the 5-year follow-up period: 33 from the study cohort (0.77% of subjects who underwent an appendectomy) and 60 from the comparison cohort (0.47% of comparison subjects) (p

AB - Many studies have reported a possible association of an appendectomy with rheumatoid arthritis (RA). However, findings of the relationship between an appendectomy and RA remain inconsistent. Furthermore, all such studies were conducted in Western societies, and relevant studies on the relationship between an appendectomy and RA in Asian countries are still lacking. In this study, we investigated the relationship between an appendectomy and the subsequent risk of RA using a population-based dataset. We retrieved data for this retrospective cohort study from the Taiwan "Longitudinal Health Insurance Database 2005". We included 4,294 subjects who underwent an appendectomy in the study cohort and 12,882 matched subjects in the comparison cohort. We individually tracked each subject for a 5-year period from their index date to identify those who developed RA. A stratified Cox proportional hazard regression was performed to calculate the hazard ratio (HR) and its corresponding 95% confidence interval (CI) for the subsequent development of RA during the 5-year follow-up period between subjects who underwent an appendectomy and comparison subjects. Of the sampled subjects, 93 (0.54%) received a diagnosis of RA during the 5-year follow-up period: 33 from the study cohort (0.77% of subjects who underwent an appendectomy) and 60 from the comparison cohort (0.47% of comparison subjects) (p

UR - http://www.scopus.com/inward/record.url?scp=84929323667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929323667&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0126816

DO - 10.1371/journal.pone.0126816

M3 - Article

C2 - 25970542

AN - SCOPUS:84929323667

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e0126816

ER -