An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer

Mei Ying Liao, Jun Kai Lai, Mark Yen Ping Kuo, Ruei Min Lu, Cheng Wei Lin, Ping Chang Cheng, Kang Hao Liang, Han Chung Wu

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

摘要

Epithelial cell adhesion molecule (EpCAM) is known to be overexpressed in epithelial cancers associated with enhanced malignant potential, particularly colorectal carcinoma (CRC) and head and neck squamous cell carcinoma (HNSCC). However, it is unknown whether progression of malignance can be directly inhibited by targeting EpCAM. Here, we have generated five novel monoclonal antibodies (mAbs) against EpCAM. One of these anti-EpCAM mAbs, EpAb2-6, was found to induce cancer cell apoptosis in vitro, inhibit tumor growth, and prolong the overall survival of both a pancreatic cancer metastatic mouse model and mice with human colon carcinoma xenografts. EpAb2-6 also increases the therapeutic efficacy of irinotecan, fluorouracil, and leucovorin (IFL) therapy in a colon cancer animal model and gemcitabine therapy in a pancreatic cancer animal model. Furthermore, EpAb2-6, which binds to positions Y95 and D96 of the EGF-II/TY domain of EpCAM, inhibits production of EpICD, thereby decreasing its translocation and subsequent signal activation. Collectively, our results indicate that the novel anti-EpCAM mAb can potentially be used for cancer-targeted therapy.

原文英語
頁(從 - 到)24947-24968
頁數22
期刊Oncotarget
6
發行號28
DOIs
出版狀態已發佈 - 2015
對外發佈Yes

ASJC Scopus subject areas

  • Oncology

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  • 引用此

    Liao, M. Y., Lai, J. K., Kuo, M. Y. P., Lu, R. M., Lin, C. W., Cheng, P. C., Liang, K. H., & Wu, H. C. (2015). An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer. Oncotarget, 6(28), 24947-24968. https://doi.org/10.18632/oncotarget.4453