An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells

Xu Bao Shi, Lingru Xue, Joy Yang, Ai Hong Ma, Jianjun Zhao, Ma Xu, Clifford G. Tepper, Christopher P. Evans, Hsing Jien Kung, Ralph W DeVere White

研究成果: 雜誌貢獻文章同行評審

405 引文 斯高帕斯(Scopus)

摘要

Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involved in tumorigenesis. Although aberrant expression of certain miRNAs has been discovered in CaP, their function in this disease has not yet been defined. In this study, we found differential expression of miR-125b in androgen-dependent and independent CaP cells, as well as in benign and malignant prostate tissues. Furthermore, androgen signaling was able to up-regulate the expression of miR-125b. In addition, transfection of synthetic miR-125b stimulated androgen-independent growth of CaP cells and down-regulated the expression of Bak1. Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP.
原文英語
頁(從 - 到)19983-19988
頁數6
期刊Proceedings of the National Academy of Sciences of the United States of America
104
發行號50
DOIs
出版狀態已發佈 - 12月 11 2007
對外發佈

ASJC Scopus subject areas

  • 遺傳學
  • 多學科

指紋

深入研究「An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells」主題。共同形成了獨特的指紋。

引用此