Ambient air pollution and risk of tuberculosis: A cohort study

Ting Chun Lai, Chen Yuan Chiang, Chang Fu Wu, Shiang Lin Yang, Ding Ping Liu, Chang Chuan Chan, Hsien Ho Lin

研究成果: 雜誌貢獻文章同行評審

65 引文 斯高帕斯(Scopus)


Objectives: Several respirable hazards, including smoking and indoor air pollution from biomass, were suggested to increase the risk of tuberculosis. Few studies have been conducted on ambient air pollution and tuberculosis. We investigated the association between exposure to ambient air pollution and incidence of active tuberculosis. Methods: We conducted a cohort study using 106 678 participants of a community-based screening service in Taiwan, 2005-2012. We estimated individual exposure to air pollution using data from the nearest air quality monitoring station and the road intensity within a 500 m buffer zone. The incidence of tuberculosis was ascertained from the national tuberculosis registry. Results: After a median follow-up of 6.7 years, 418 cases of tuberculosis occurred. Exposure to fine particulate matter (PM2.5) was associated with increased risk of active tuberculosis (adjusted HR: 1.39/10 μg/m3 (95% CI 0.95 to 2.03)). In addition, traffic-related air pollution including nitrogen dioxide (adjusted HR: 1.33/10 ppb; 95% CI 1.04 to 1.70), nitrogen oxides (adjusted HR: 1.21/10 ppb; 95% CI 1.04 to 1.41) and carbon monoxide (adjusted HR: 1.89/ppm; 95% CI 0.78 to 4.58) was associated with tuberculosis risk. There was a non-significant trend between the length of major roads in the neighbourhood and culture-confirmed tuberculosis (adjusted HR: 1.04/km; 95% CI 0.995 to 1.09). Conclusions: Our study revealed a possible link between ambient air pollution and risk of active tuberculosis. Since people from developing countries continue to be exposed to high levels of ambient air pollution and to experience high rates of tuberculosis, the impact of worsening air pollution on global tuberculosis control warrants further investigation.

頁(從 - 到)56-61
期刊Occupational and Environmental Medicine
出版狀態已發佈 - 1月 1 2016

ASJC Scopus subject areas

  • 公共衛生、環境和職業健康


深入研究「Ambient air pollution and risk of tuberculosis: A cohort study」主題。共同形成了獨特的指紋。