摘要

Objective: To investigate the risk of stroke in patients clinically diagnosed with Alzheimer disease (AD) compared with non-AD patients with similar vascular risk factors. Methods: Using data obtained from Taiwan's National Health Insurance Research Database, we evaluated the risk of ischemic stroke (IS) and intracerebral hemorrhage (ICH) in patients with AD (n = 980) who had no history of stroke, vascular dementia, or other cerebral degenerative diseases. Our evaluation period spanned from 2000 to 2010. We performed a 1:5 case-control matched analysis, in which cases were matched to controls according to their estimated propensity scores, which were based on demographics and existing vascular risk factors. This approach reduced selection bias. Cox proportional hazards regression analysis was then used to estimate the risk of IS and ICH in AD, conditional for matched pairs. Results: Overall, patients with AD had a higher risk of IS and ICH than those without AD. The incidence of IS in AD cases and non-AD controls was 37.8 and 23.2 per 1,000 person-years, with an adjusted hazard ratio of 1.66 (95% confidence interval, 1.37-2.01, p <0.001). The incidence of ICH in AD cases and non-AD controls was 5.2 and 3.0 per 1,000 person-years, with an adjusted hazard ratio of 1.70 (95% confidence interval, 1.03-2.79, p = 0.037). Conclusion: Clinical diagnosis of AD is associated with considerably increased risk of stroke development.
原文英語
頁(從 - 到)705-711
頁數7
期刊Neurology
80
發行號8
DOIs
出版狀態已發佈 - 二月 19 2013

指紋

Alzheimer Disease
Cohort Studies
Stroke
Cerebral Hemorrhage
Population
Confidence Intervals
Propensity Score
Vascular Dementia
Alzheimer's Disease
Cohort
Selection Bias
Incidence
National Health Programs
Taiwan
Regression Analysis
Demography
Databases
Research
Hazard

Keywords

  • Alzheimer Disease
  • Case-Control Studies
  • Cohort Studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

引用此文

Alzheimer disease and risk of stroke : A population-based cohort study. / Chi, Nai Fang; Chien, Li Nien; Ku, Hsiao Lun; Hu, Chaur Jong; Chiou, Hung Yi.

於: Neurology, 卷 80, 編號 8, 19.02.2013, p. 705-711.

研究成果: 雜誌貢獻文章

@article{73cecf8a1f554ead8d129633e273b0c4,
title = "Alzheimer disease and risk of stroke: A population-based cohort study",
abstract = "Objective: To investigate the risk of stroke in patients clinically diagnosed with Alzheimer disease (AD) compared with non-AD patients with similar vascular risk factors. Methods: Using data obtained from Taiwan's National Health Insurance Research Database, we evaluated the risk of ischemic stroke (IS) and intracerebral hemorrhage (ICH) in patients with AD (n = 980) who had no history of stroke, vascular dementia, or other cerebral degenerative diseases. Our evaluation period spanned from 2000 to 2010. We performed a 1:5 case-control matched analysis, in which cases were matched to controls according to their estimated propensity scores, which were based on demographics and existing vascular risk factors. This approach reduced selection bias. Cox proportional hazards regression analysis was then used to estimate the risk of IS and ICH in AD, conditional for matched pairs. Results: Overall, patients with AD had a higher risk of IS and ICH than those without AD. The incidence of IS in AD cases and non-AD controls was 37.8 and 23.2 per 1,000 person-years, with an adjusted hazard ratio of 1.66 (95{\%} confidence interval, 1.37-2.01, p <0.001). The incidence of ICH in AD cases and non-AD controls was 5.2 and 3.0 per 1,000 person-years, with an adjusted hazard ratio of 1.70 (95{\%} confidence interval, 1.03-2.79, p = 0.037). Conclusion: Clinical diagnosis of AD is associated with considerably increased risk of stroke development.",
keywords = "Alzheimer disease, brain hemorrhage, brain ischemia, Alzheimer Disease, Case-Control Studies, Cohort Studies",
author = "Chi, {Nai Fang} and Chien, {Li Nien} and Ku, {Hsiao Lun} and Hu, {Chaur Jong} and Chiou, {Hung Yi}",
year = "2013",
month = "2",
day = "19",
doi = "10.1212/WNL.0b013e31828250af",
language = "English",
volume = "80",
pages = "705--711",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Alzheimer disease and risk of stroke

T2 - A population-based cohort study

AU - Chi, Nai Fang

AU - Chien, Li Nien

AU - Ku, Hsiao Lun

AU - Hu, Chaur Jong

AU - Chiou, Hung Yi

PY - 2013/2/19

Y1 - 2013/2/19

N2 - Objective: To investigate the risk of stroke in patients clinically diagnosed with Alzheimer disease (AD) compared with non-AD patients with similar vascular risk factors. Methods: Using data obtained from Taiwan's National Health Insurance Research Database, we evaluated the risk of ischemic stroke (IS) and intracerebral hemorrhage (ICH) in patients with AD (n = 980) who had no history of stroke, vascular dementia, or other cerebral degenerative diseases. Our evaluation period spanned from 2000 to 2010. We performed a 1:5 case-control matched analysis, in which cases were matched to controls according to their estimated propensity scores, which were based on demographics and existing vascular risk factors. This approach reduced selection bias. Cox proportional hazards regression analysis was then used to estimate the risk of IS and ICH in AD, conditional for matched pairs. Results: Overall, patients with AD had a higher risk of IS and ICH than those without AD. The incidence of IS in AD cases and non-AD controls was 37.8 and 23.2 per 1,000 person-years, with an adjusted hazard ratio of 1.66 (95% confidence interval, 1.37-2.01, p <0.001). The incidence of ICH in AD cases and non-AD controls was 5.2 and 3.0 per 1,000 person-years, with an adjusted hazard ratio of 1.70 (95% confidence interval, 1.03-2.79, p = 0.037). Conclusion: Clinical diagnosis of AD is associated with considerably increased risk of stroke development.

AB - Objective: To investigate the risk of stroke in patients clinically diagnosed with Alzheimer disease (AD) compared with non-AD patients with similar vascular risk factors. Methods: Using data obtained from Taiwan's National Health Insurance Research Database, we evaluated the risk of ischemic stroke (IS) and intracerebral hemorrhage (ICH) in patients with AD (n = 980) who had no history of stroke, vascular dementia, or other cerebral degenerative diseases. Our evaluation period spanned from 2000 to 2010. We performed a 1:5 case-control matched analysis, in which cases were matched to controls according to their estimated propensity scores, which were based on demographics and existing vascular risk factors. This approach reduced selection bias. Cox proportional hazards regression analysis was then used to estimate the risk of IS and ICH in AD, conditional for matched pairs. Results: Overall, patients with AD had a higher risk of IS and ICH than those without AD. The incidence of IS in AD cases and non-AD controls was 37.8 and 23.2 per 1,000 person-years, with an adjusted hazard ratio of 1.66 (95% confidence interval, 1.37-2.01, p <0.001). The incidence of ICH in AD cases and non-AD controls was 5.2 and 3.0 per 1,000 person-years, with an adjusted hazard ratio of 1.70 (95% confidence interval, 1.03-2.79, p = 0.037). Conclusion: Clinical diagnosis of AD is associated with considerably increased risk of stroke development.

KW - Alzheimer disease

KW - brain hemorrhage

KW - brain ischemia

KW - Alzheimer Disease

KW - Case-Control Studies

KW - Cohort Studies

UR - http://www.scopus.com/inward/record.url?scp=84876238102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876238102&partnerID=8YFLogxK

U2 - 10.1212/WNL.0b013e31828250af

DO - 10.1212/WNL.0b013e31828250af

M3 - Article

C2 - 23303851

AN - SCOPUS:84876238102

VL - 80

SP - 705

EP - 711

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 8

ER -