Alternanthera paronychioides protects pancreatic β-cells from glucotoxicity by its antioxidant, antiapoptotic and insulin secretagogue actions

Chi Hao Wu, Hsin Tzu Hsieh, Jer An Lin, Gow Chin Yen

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

The antioxidant and antiglucotoxic effects of Alternanthera paronychioides on pancreatic β-cell were investigated. Antioxidant assays demonstrated that ethanol extracts of A. paronychioides (EEAP) exhibited the highest antioxidant activity, which also had the highest phenolic and flavonoid contents. Two major polyphenolics, ferulic acid and quercetin, were identified from EEAP by HPLC-DAD. Effects of EEAP, ferulic acid and quercetin on high glucose (25 mmol/L)-induced pancreatic β-cell apoptosis and dysfunction were further evaluated. Results showed that EEAP and quercetin but not ferulic acid protected β-cells from glucotoxicity through several mechanisms, including: (1) maintaining β-cell viability; (2) suppressing reactive oxygen species production; (3) reducing characteristic features of apoptosis; (4) inhibiting the activation of caspase-9 and caspase-3 and the cleavage of poly (ADP-ribose) polymerase; (5) upregulating pancreatic and duodenal homeobox 1 gene expression and the insulin secretagogue action of pancreatic β-cells. These findings may shed light on the preventive actions of A. paronychioides on diabetic glucotoxicity.

原文英語
頁(從 - 到)362-370
頁數9
期刊Food Chemistry
139
發行號1-4
DOIs
出版狀態已發佈 - 八月 15 2013

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

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