Altered temporal variance and neural synchronization of spontaneous brain activity in anesthesia

Zirui Huang, Zhiyao Wang, Jianfeng Zhang, Rui Dai, Jinsong Wu, Yuan Li, Weimin Liang, Ying Mao, Zhong Yang, Giles Holland, Jun Zhang, Georg Northoff

研究成果: 雜誌貢獻文章同行評審

48 引文 斯高帕斯(Scopus)

摘要

Recent studies at the cellular and regional levels have pointed out the multifaceted importance of neural synchronization and temporal variance of neural activity. For example, neural synchronization and temporal variance has been shown by us to be altered in patients in the vegetative state (VS). This finding nonetheless leaves open the question of whether these abnormalities are specific to VS or rather more generally related to the absence of consciousness. The aim of our study was to investigate the changes of inter- and intra-regional neural synchronization and temporal variance of resting state activity in anesthetic-induced unconsciousness state. Applying an intra-subject design, we compared resting state activity in functional magnetic resonance imaging (fMRI) between awake versus anesthetized states in the same subjects. Replicating previous studies, we observed reduced functional connectivity within the default mode network (DMN) and thalamocortical network in the anesthetized state. Importantly, intra-regional synchronization as measured by regional homogeneity (ReHo) and temporal variance as measured by standard deviation (SD) of the BOLD signal were significantly reduced in especially the cortical midline regions, while increased in the lateral cortical areas in the anesthetized state. We further found significant frequency-dependent effects of SD in the thalamus, which showed abnormally high SD in Slow-5 (0.01-0.027 Hz) in the anesthetized state. Our results show for the first time of altered temporal variance of resting state activity in anesthesia. Combined with our findings in the vegetative state, these findings suggest a close relationship between temporal variance, neural synchronization and consciousness.
原文英語
頁(從 - 到)5368-5378
頁數11
期刊Human Brain Mapping
35
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2014
對外發佈

ASJC Scopus subject areas

  • 神經病學(臨床)
  • 解剖學
  • 神經內科
  • 放射學、核子醫學和影像學
  • 放射與超音波技術
  • 醫藥 (全部)

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