Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder

A sibling study using tract-based automatic analysis

Yu Chun Lo, Yu Jen Chen, Yung Chin Hsu, Yi Ling Chien, Susan Shur Fen Gau, Wen Yih Isaac Tseng

研究成果: 雜誌貢獻文章

摘要

Investigating social behaviors and brain structural alterations in unaffected siblings of individuals with autism spectrum disorder (ASD) may help identify intermediate phenotypes of social communication deficits in ASD. This study hypothesized that such intermediate phenotypes could be identified in white matter tracts of the social communication model that exhibited reduced tract integrity and associations with social communication deficits. Boys with ASD (N = 30), unaffected male siblings (N = 27), and typically developing (TD) boys (N = 30) underwent clinical evaluation and MRI scanning. Group differences in generalized fractional anisotropy (GFA) values, a white matter integrity index derived from diffusion MRI data, and the relationships of GFA with the Social Responsiveness Scale (SRS) scores and the Child Behavior Checklist (CBCL/4–18) scores were investigated. Significant differences were found in the GFA values of the frontal aslant tract (FAT) among the three groups, with the decreasing order of GFA from TD to siblings to ASD. The GFA values of the FAT were associated with the social communication scores (on the SRS) in the sibling group, and those of the superior longitudinal fasciculus III were associated with the social problems scores (on the CBCL/4–18) in the boys with ASD. Due to the altered tract integrity and association with social communication deficits in the unaffected siblings of individuals with ASD, the FAT might be a heritable neural basis for social communication deficits of ASD. Autism Res 2018.
原文英語
期刊Autism Research
DOIs
出版狀態已發佈 - 2019

指紋

Siblings
Anisotropy
Communication
Phenotype
Diffusion Magnetic Resonance Imaging
Social Behavior
Social Problems
Child Behavior
Autistic Disorder
Autism Spectrum Disorder
Checklist
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Genetics(clinical)

引用此文

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder : A sibling study using tract-based automatic analysis. / Lo, Yu Chun; Chen, Yu Jen; Hsu, Yung Chin; Chien, Yi Ling; Gau, Susan Shur Fen; Tseng, Wen Yih Isaac.

於: Autism Research, 2019.

研究成果: 雜誌貢獻文章

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abstract = "Investigating social behaviors and brain structural alterations in unaffected siblings of individuals with autism spectrum disorder (ASD) may help identify intermediate phenotypes of social communication deficits in ASD. This study hypothesized that such intermediate phenotypes could be identified in white matter tracts of the social communication model that exhibited reduced tract integrity and associations with social communication deficits. Boys with ASD (N = 30), unaffected male siblings (N = 27), and typically developing (TD) boys (N = 30) underwent clinical evaluation and MRI scanning. Group differences in generalized fractional anisotropy (GFA) values, a white matter integrity index derived from diffusion MRI data, and the relationships of GFA with the Social Responsiveness Scale (SRS) scores and the Child Behavior Checklist (CBCL/4–18) scores were investigated. Significant differences were found in the GFA values of the frontal aslant tract (FAT) among the three groups, with the decreasing order of GFA from TD to siblings to ASD. The GFA values of the FAT were associated with the social communication scores (on the SRS) in the sibling group, and those of the superior longitudinal fasciculus III were associated with the social problems scores (on the CBCL/4–18) in the boys with ASD. Due to the altered tract integrity and association with social communication deficits in the unaffected siblings of individuals with ASD, the FAT might be a heritable neural basis for social communication deficits of ASD. Autism Res 2018.",
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