Alterations in theophylline metabolism during the first year of life

Donna M. Kraus, James H. Fischer, Shirley J. Reitz, Susan A. Kecskes, Tsu F. Yeh, Kristine M. McCulloch, Elizabeth C. Tung, Michael J. Cwik

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76 引文 斯高帕斯(Scopus)

摘要

Maturational changes in theophylline disposition were evaluated in 52 infants (gestational age, 24 to 40 weeks; postnatal age, 2 to 69 weeks) receiving maintenance theophylline therapy. Theophylline and metabolites were measured in serum and urine at steady state, and the influence of clinical parameters on the maturational changes was analyzed by multiple stepwise linear regression. Theophylline clearance and urine metabolite pattern reached adult values at 55 weeks' postconceptional age. Serum caffeine concentrations greater than 1 µg/ml occurred in infants up to 50 weeks' postconceptional age. Disappearance of serum caffeine concentrations and maturation of theophylline clearance were primarily related (p < 0.001) to development of the demethylation pathway to 3‐methylxanthine. Postconceptional age was the major factor (p < 0.001) explaining the interpatient variability in theophylline clearance (r2 = 0.57), serum caffeine to theophylline ratio (r2 = 0.46), and urinary excretion of theophylline (r2 = 0.51), caffeine (r2 = 0.49), 1,3‐methyluric acid (r2 = 0.32), 1‐methyluric acid (r2 = 0.53), and 3‐methylxanthine (r2 = 0.58). Our findings indicate that postconceptional age rather than postnatal age should be used as a maturational marker during theophylline therapy in infancy. Clinical Pharmacology and Therapeutics (1993) 54, 351–359; doi:

原文英語
頁(從 - 到)351-359
頁數9
期刊Clinical Pharmacology & Therapeutics
54
發行號4
DOIs
出版狀態已發佈 - 1月 1 1993
對外發佈

ASJC Scopus subject areas

  • 藥理
  • 藥學(醫學)

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