Alterations in physiological functions and in brain monoamine content in the sympathectomized rats.

L. S. Lin, W. T. Chiu, M. T. Lin, C. J. Shih

研究成果: 雜誌貢獻文章同行評審

摘要

In the present study, we conducted pre-ganglionic decentralization (or sympathetic trunk resection) of the superior cervical ganglia and observed alterations in several physiological functions and in the monoamine content of different brain regions. Over an ambient temperature range of 8-30 degrees C, these sympathectomized rats maintained their rectal temperatures within a normal limit displayed by the intact controls. These sympathectomized animals, although showing no change in the level of spontaneous pain threshold or motor activity, did display an increased sensitivity of analgesic responses to morphine administration or locomotor stimulant responses to amphetamine administration. Biochemical examination revealed that these sympathectomized animals had a higher level of norepinephrine, dopamine or 5-hydroxytryptamine in the hypothalamus, as well as a higher level of dopamine in the corpus striatum. However, in the brainstem, these sympathectomized animals had a unaltered monoamine level. The data indicate that, in a sympathectomized condition, changes in the monoamine content of different brain regions may be correlated with the above-mentioned alterations in somatosensory and motor neural functions.

原文英語
頁(從 - 到)191-195
頁數5
期刊Proceedings of the National Science Council, Republic of China. Part B, Life sciences
10
發行號3
出版狀態已發佈 - 七月 1986
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

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