摘要
Air pollution is known to increase the risk of pneumonia. However, the effects of air pollution on the pleural effusion of patients with pneumonia are unclear. The objective of this study was to investigate alterations in inflammatory–immune biomarkers by air pollution in patients with pneumonia by analyzing their pleural effusion. Patients who had undergone thoracentesis to drain their pleural effusion in a hospital were recruited for this study. Patients with pneumonia and those with congestive heart failure respectively served as the case and control groups. We observed that an increase of 1 ppb in one-year NO2 was associated with a decrease of 0.105 ng/mL in cluster of differentiation 62 (CD62) (95% confidence interval (CI) = -0.085, -0.004, p < 0.05) in the pleural effusion. Furthermore, we observed that an increase in one-year 1 ppb of NO2 was associated with a decrease of 0.026 ng/mL in molybdenum (Mo) (95% CI = -0.138, -0.020, p < 0.05). An increase in one-year 1 ppb of SO2 was associated with a decrease of 0.531 ng/mL in zinc (95% CI = -0.164, -0.006, p < 0.05). Also, an increase in one-year 1 ppb of O3 was associated with a decrease of 0.025 ng/mL in Mo (95% CI = -0.372, -0.053, p < 0.05). In conclusion, air pollution exposure, especially gaseous pollution, may be associated with the regulation of immune responses and changes in metal levels in the pleural effusion of pneumonia patients.
| 原文 | 英語 |
|---|---|
| 文章編號 | 705 |
| 期刊 | International Journal of Environmental Research and Public Health |
| 卷 | 16 |
| 發行號 | 5 |
| DOIs | |
| 出版狀態 | 已發佈 - 三月 1 2019 |
指紋
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
引用此文
Alterations by air pollution in inflammation and metals in pleural effusion of pneumonia patients. / Bai, Kuan Jen; Chuang, Kai Jen; Chen, Jen Kun; Tsai, Cheng Yu; Yang, You Lan; Chang, Chih Cheng; Chen, Tzu Tao; Lee, Chun Nin; Feng, Po Hao; Chen, Kuan Yuan; Lee, Kang Yun; Su, Chein Ling; Ho, Shu Chuan; Wu, Sheng Ming; Chuang, Hsiao Chi.
於: International Journal of Environmental Research and Public Health, 卷 16, 編號 5, 705, 01.03.2019.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Alterations by air pollution in inflammation and metals in pleural effusion of pneumonia patients
AU - Bai, Kuan Jen
AU - Chuang, Kai Jen
AU - Chen, Jen Kun
AU - Tsai, Cheng Yu
AU - Yang, You Lan
AU - Chang, Chih Cheng
AU - Chen, Tzu Tao
AU - Lee, Chun Nin
AU - Feng, Po Hao
AU - Chen, Kuan Yuan
AU - Lee, Kang Yun
AU - Su, Chein Ling
AU - Ho, Shu Chuan
AU - Wu, Sheng Ming
AU - Chuang, Hsiao Chi
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Air pollution is known to increase the risk of pneumonia. However, the effects of air pollution on the pleural effusion of patients with pneumonia are unclear. The objective of this study was to investigate alterations in inflammatory–immune biomarkers by air pollution in patients with pneumonia by analyzing their pleural effusion. Patients who had undergone thoracentesis to drain their pleural effusion in a hospital were recruited for this study. Patients with pneumonia and those with congestive heart failure respectively served as the case and control groups. We observed that an increase of 1 ppb in one-year NO2 was associated with a decrease of 0.105 ng/mL in cluster of differentiation 62 (CD62) (95% confidence interval (CI) = -0.085, -0.004, p < 0.05) in the pleural effusion. Furthermore, we observed that an increase in one-year 1 ppb of NO2 was associated with a decrease of 0.026 ng/mL in molybdenum (Mo) (95% CI = -0.138, -0.020, p < 0.05). An increase in one-year 1 ppb of SO2 was associated with a decrease of 0.531 ng/mL in zinc (95% CI = -0.164, -0.006, p < 0.05). Also, an increase in one-year 1 ppb of O3 was associated with a decrease of 0.025 ng/mL in Mo (95% CI = -0.372, -0.053, p < 0.05). In conclusion, air pollution exposure, especially gaseous pollution, may be associated with the regulation of immune responses and changes in metal levels in the pleural effusion of pneumonia patients.
AB - Air pollution is known to increase the risk of pneumonia. However, the effects of air pollution on the pleural effusion of patients with pneumonia are unclear. The objective of this study was to investigate alterations in inflammatory–immune biomarkers by air pollution in patients with pneumonia by analyzing their pleural effusion. Patients who had undergone thoracentesis to drain their pleural effusion in a hospital were recruited for this study. Patients with pneumonia and those with congestive heart failure respectively served as the case and control groups. We observed that an increase of 1 ppb in one-year NO2 was associated with a decrease of 0.105 ng/mL in cluster of differentiation 62 (CD62) (95% confidence interval (CI) = -0.085, -0.004, p < 0.05) in the pleural effusion. Furthermore, we observed that an increase in one-year 1 ppb of NO2 was associated with a decrease of 0.026 ng/mL in molybdenum (Mo) (95% CI = -0.138, -0.020, p < 0.05). An increase in one-year 1 ppb of SO2 was associated with a decrease of 0.531 ng/mL in zinc (95% CI = -0.164, -0.006, p < 0.05). Also, an increase in one-year 1 ppb of O3 was associated with a decrease of 0.025 ng/mL in Mo (95% CI = -0.372, -0.053, p < 0.05). In conclusion, air pollution exposure, especially gaseous pollution, may be associated with the regulation of immune responses and changes in metal levels in the pleural effusion of pneumonia patients.
KW - Air pollution
KW - Heart failure
KW - Immune function
KW - Infection
KW - Metal
UR - http://www.scopus.com/inward/record.url?scp=85067230740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067230740&partnerID=8YFLogxK
U2 - 10.3390/ijerph16050705
DO - 10.3390/ijerph16050705
M3 - Article
VL - 16
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 5
M1 - 705
ER -