Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development

Ka-Wai Tam, Chi Tang Ho, Wen Jui Lee, Shih-Hsin Tu, Ching Shui Huang, Ching Shyang Chen, Chia-Hwa Lee, Chih-Hsiung Wu, Yuan-Soon Ho

研究成果: 雜誌貢獻文章

14 引文 (Scopus)

摘要

Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.
原文英語
頁(從 - 到)1015-1021
頁數7
期刊Food Chemistry
138
發行號2-3
DOIs
出版狀態已發佈 - 六月 1 2013

指紋

Tocopherols
tocopherols
breast neoplasms
breasts
Breast
epithelial cells
protein synthesis
Epithelial Cells
Breast Neoplasms
Vitamin E
Cell Survival
Proteins
Dietary supplements
Cells
ErbB-2 Receptor
cell viability
vitamin E
Tissue
Succinic Acid
Dietary Supplements

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

引用此文

Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development. / Tam, Ka-Wai; Ho, Chi Tang; Lee, Wen Jui; Tu, Shih-Hsin; Huang, Ching Shui; Chen, Ching Shyang; Lee, Chia-Hwa; Wu, Chih-Hsiung; Ho, Yuan-Soon.

於: Food Chemistry, 卷 138, 編號 2-3, 01.06.2013, p. 1015-1021.

研究成果: 雜誌貢獻文章

Tam, Ka-Wai ; Ho, Chi Tang ; Lee, Wen Jui ; Tu, Shih-Hsin ; Huang, Ching Shui ; Chen, Ching Shyang ; Lee, Chia-Hwa ; Wu, Chih-Hsiung ; Ho, Yuan-Soon. / Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development. 於: Food Chemistry. 2013 ; 卷 138, 編號 2-3. 頁 1015-1021.
@article{e87161899ae547ddb8c6247b64b43bba,
title = "Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development",
abstract = "Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.",
keywords = "α-Tocopherol-associated protein, Breast cancer, Her2/neu receptor, Vitamin E",
author = "Ka-Wai Tam and Ho, {Chi Tang} and Lee, {Wen Jui} and Shih-Hsin Tu and Huang, {Ching Shui} and Chen, {Ching Shyang} and Chia-Hwa Lee and Chih-Hsiung Wu and Yuan-Soon Ho",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.foodchem.2012.09.147",
language = "English",
volume = "138",
pages = "1015--1021",
journal = "Food Chemistry",
issn = "0308-8146",
publisher = "Elsevier Ltd",
number = "2-3",

}

TY - JOUR

T1 - Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development

AU - Tam, Ka-Wai

AU - Ho, Chi Tang

AU - Lee, Wen Jui

AU - Tu, Shih-Hsin

AU - Huang, Ching Shui

AU - Chen, Ching Shyang

AU - Lee, Chia-Hwa

AU - Wu, Chih-Hsiung

AU - Ho, Yuan-Soon

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.

AB - Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.

KW - α-Tocopherol-associated protein

KW - Breast cancer

KW - Her2/neu receptor

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=84873739923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873739923&partnerID=8YFLogxK

U2 - 10.1016/j.foodchem.2012.09.147

DO - 10.1016/j.foodchem.2012.09.147

M3 - Article

C2 - 23411208

AN - SCOPUS:84873739923

VL - 138

SP - 1015

EP - 1021

JO - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

IS - 2-3

ER -