Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development

Ka-Wai Tam, Chi Tang Ho, Wen Jui Lee, Shih-Hsin Tu, Ching Shui Huang, Ching Shyang Chen, Chia-Hwa Lee, Chih-Hsiung Wu, Yuan-Soon Ho

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.
原文英語
頁(從 - 到)1015-1021
頁數7
期刊Food Chemistry
138
發行號2-3
DOIs
出版狀態已發佈 - 六月 1 2013

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

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