Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis

Te Sheng Chang, Yu Chih Wu, Shui Yi Tung, Kuo Liang Wei, Yung Yu Hsieh, Hao Chun Huang, Wei Ming Chen, Chien Heng Shen, Chang Hsien Lu, Cheng Shyong Wu, Ying Huang Tsai, Yen Hua Huang

研究成果: 雜誌貢獻文章

43 引文 (Scopus)

摘要

Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC), and all liver study societies recommend HCC surveillance in patients with cirrhosis. However, no ideal modality for HCC surveillance has been determined. The aim of this study is to assess the effectiveness of α-fetoprotein (AFP) measurement in HCC surveillance.METHODS:In this retrospective analysis, all patients with cirrhosis, who received HCC surveillance through ultrasound (US) and AFP measurement between January 2002 and July 2010, were followed up until June 2013. The performance effectiveness of surveillance using AFP, US, or both in HCC detection was compared.RESULTS:Overall, 1,597 patients were followed for a median duration of 4.75 (range 1.42-12) years. Over the 8563.25-person-year follow-up period, 363 patients (22.7%) developed HCCs. For HCC detection, the area under the receiver operator characteristic curve of surveillance AFP was 0.844 (95% confidence interval: 0.820-0.868, P

原文英語
頁(從 - 到)836-844
頁數9
期刊American Journal of Gastroenterology
110
發行號6
DOIs
出版狀態已發佈 - 六月 10 2015

指紋

alpha-Fetoproteins
Hepatocellular Carcinoma
Fibrosis
Fetal Proteins
Liver Cirrhosis
Confidence Intervals
Liver

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

引用此文

Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis. / Chang, Te Sheng; Wu, Yu Chih; Tung, Shui Yi; Wei, Kuo Liang; Hsieh, Yung Yu; Huang, Hao Chun; Chen, Wei Ming; Shen, Chien Heng; Lu, Chang Hsien; Wu, Cheng Shyong; Tsai, Ying Huang; Huang, Yen Hua.

於: American Journal of Gastroenterology, 卷 110, 編號 6, 10.06.2015, p. 836-844.

研究成果: 雜誌貢獻文章

Chang, TS, Wu, YC, Tung, SY, Wei, KL, Hsieh, YY, Huang, HC, Chen, WM, Shen, CH, Lu, CH, Wu, CS, Tsai, YH & Huang, YH 2015, 'Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis', American Journal of Gastroenterology, 卷 110, 編號 6, 頁 836-844. https://doi.org/10.1038/ajg.2015.100
Chang, Te Sheng ; Wu, Yu Chih ; Tung, Shui Yi ; Wei, Kuo Liang ; Hsieh, Yung Yu ; Huang, Hao Chun ; Chen, Wei Ming ; Shen, Chien Heng ; Lu, Chang Hsien ; Wu, Cheng Shyong ; Tsai, Ying Huang ; Huang, Yen Hua. / Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis. 於: American Journal of Gastroenterology. 2015 ; 卷 110, 編號 6. 頁 836-844.
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abstract = "Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC), and all liver study societies recommend HCC surveillance in patients with cirrhosis. However, no ideal modality for HCC surveillance has been determined. The aim of this study is to assess the effectiveness of α-fetoprotein (AFP) measurement in HCC surveillance.METHODS:In this retrospective analysis, all patients with cirrhosis, who received HCC surveillance through ultrasound (US) and AFP measurement between January 2002 and July 2010, were followed up until June 2013. The performance effectiveness of surveillance using AFP, US, or both in HCC detection was compared.RESULTS:Overall, 1,597 patients were followed for a median duration of 4.75 (range 1.42-12) years. Over the 8563.25-person-year follow-up period, 363 patients (22.7{\%}) developed HCCs. For HCC detection, the area under the receiver operator characteristic curve of surveillance AFP was 0.844 (95{\%} confidence interval: 0.820-0.868, P",
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AU - Chen, Wei Ming

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