Alpha coefficient of dose-response for chromosome translocations measured by FISH in human lymphocytes exposed to chronic 60Co gamma rays at body temperature

W. A. Hsieh, W. Deng, W. P. Chang, N. Galvan, C. L. Owens, D. P. Morrison, K. L. Gale, J. N. Lucas

研究成果: 雜誌貢獻文章同行評審

22 引文 斯高帕斯(Scopus)

摘要

Purpose: To measure the alpha coefficient, the initial slope of the translocation dose-response curve, for 60Co γ-rays in human lymphocytes. Materials and methods: Human lymphocytes were exposed to 0, 0.32, 0.62 and 0.92 Gy of chronic 60Co γ-rays under conditions that reduce the metabolic stress to the cells. Chromosome translocation frequencies were measured using fluorescence in situ hybridization with a whole-chromosome probe cocktail specific for chromosomes 1, 2, 4 (orange) and 3, 5, 6 (green). Results: A total of 72 383 metaphases were analysed (33 429 in exposed cells) in two individuals. The shape of the dose-response curves for translocations was linear, and alpha coefficient was measured as 0.024 ± 0.002 translocations per cell per Gy for the combined data for two 24 year old male donors. Conclusion: The alpha coefficients measured after chronic exposure were in good agreement with that reported in the literature for acute, low-dose exposure of human lymphocytes to 60Co γ-rays.

原文英語
頁(從 - 到)435-439
頁數5
期刊International Journal of Radiation Biology
75
發行號4
出版狀態已發佈 - 1999
對外發佈

ASJC Scopus subject areas

  • 農業與生物科學(雜項)
  • 放射學、核子醫學和影像學
  • 放射與超音波技術
  • 核能與工程
  • 輻射

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