Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models

Hsiao Chi Chuang, Ta Chih Hsiao, Cheng Kuan Wu, Hui Hsien Chang, Chii Hong Lee, Chih Cheng Chang, Tsun Jen Cheng

研究成果: 雜誌貢獻文章同行評審

27 引文 斯高帕斯(Scopus)

摘要

Silver nanoparticles (AgNP) have been associated with the exacerbation of airway hyperresponsiveness. However, the allergenicity and toxicology of AgNP in healthy and allergic individuals are unclear. We investigated the pathophysiological responses to AgNP inhalation in a murine model of asthma. Continuous and stable levels of 33 nm AgNP were maintained at 3.3 mg/m3 during the experimental period. AgNP exposure concomitant with ovalbumin challenge increased the enhanced pause (Penh) in the control and allergic groups. AgNP evoked neutrophil, lymphocyte and eosinophil infiltration into the airways and elevated the levels of allergic markers (immunoglobulin E [IgE] and leukotriene E4 [LTE4]), the type 2 T helper (Th2) cytokine interleukin-13 (IL-13), and oxidative stress (8-hydroxy-2′-deoxyguanosine [8-OHdG]) in healthy and allergic mice. Bronchocentric interstitial inflammation was observed after AgNP inhalation. After inhalation, the AgNP accumulated predominantly in the lungs, and trivial amounts of AgNP were excreted in the urine and feces. Furthermore, the AgNP induced inflammatory responses in the peritoneum. The inhalation of AgNP may present safety concerns in healthy and susceptible individuals.

原文英語
頁(從 - 到)4495-4506
頁數12
期刊International Journal of Nanomedicine
8
DOIs
出版狀態已發佈 - 十一月 22 2013

ASJC Scopus subject areas

  • 生物物理學
  • 生物工程
  • 生物材料
  • 有機化學
  • 藥物發現

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