TY - JOUR
T1 - Aliphatic phenolic ethers from trichobotrys effusa
AU - Chen, Jih Jung
AU - Wang, Shih Wei
AU - Hsiao, Hui Yun
AU - Lee, Ming Shian
AU - Ju, Yu Min
AU - Kuo, Yueh Hsiung
AU - Li, Zong-Huei
PY - 2014/5/23
Y1 - 2014/5/23
N2 - Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).
AB - Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).
UR - http://www.scopus.com/inward/record.url?scp=84901674009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901674009&partnerID=8YFLogxK
U2 - 10.1021/np400776y
DO - 10.1021/np400776y
M3 - Article
C2 - 24797798
AN - SCOPUS:84901674009
SN - 0163-3864
VL - 77
SP - 1097
EP - 1101
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -
