Aliphatic phenolic ethers from trichobotrys effusa

Jih Jung Chen, Shih Wei Wang, Hui Yun Hsiao, Ming Shian Lee, Yu Min Ju, Yueh Hsiung Kuo, Zong-Huei Li

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).
原文英語
頁(從 - 到)1097-1101
頁數5
期刊Journal of Natural Products
77
發行號5
DOIs
出版狀態已發佈 - 五月 23 2014

ASJC Scopus subject areas

  • 藥物發現
  • 藥理
  • 藥學科學
  • 分析化學
  • 有機化學
  • 分子醫學
  • 補充和替代醫學

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