摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 1504-1513 |
| 頁數 | 10 |
| 期刊 | Alcoholism: Clinical and Experimental Research |
| 卷 | 29 |
| 發行號 | 8 |
| DOIs | |
| 出版狀態 | 已發佈 - 八月 1 2005 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
- Psychiatry and Mental health
引用此文
Alcoholic neurobiology : Changes in dependence and recovery. / Crews, Fulton T.; Buckley, Tracey; Dodd, Peter R.; Ende, Gabriele; Foley, Nina; Harper, Clive; He, Jun; Innes, David; Loh, El Wui; Pfefferbaum, Adolf; Zou, Jian; Sullivan, Edith V.
於: Alcoholism: Clinical and Experimental Research, 卷 29, 編號 8, 01.08.2005, p. 1504-1513.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Alcoholic neurobiology
T2 - Changes in dependence and recovery
AU - Crews, Fulton T.
AU - Buckley, Tracey
AU - Dodd, Peter R.
AU - Ende, Gabriele
AU - Foley, Nina
AU - Harper, Clive
AU - He, Jun
AU - Innes, David
AU - Loh, El Wui
AU - Pfefferbaum, Adolf
AU - Zou, Jian
AU - Sullivan, Edith V.
PY - 2005/8/1
Y1 - 2005/8/1
N2 - This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October, 2004. Chronic alcoholism follows a fluctuating course, which provides a naturalistic experiment in vulnerability, resilience, and recovery of human neural systems in response to presence, absence, and history of the neurotoxic effects of alcoholism. Alcohol dependence is a progressive chronic disease that is associated with changes in neuroanatomy, neurophysiology, neural gene expression, psychology, and behavior. Specifically, alcohol dependence is characterized by a neuropsychological profile of mild to moderate impairment in executive functions, visuospatial abilities, and postural stability, together with relative sparing of declarative memory, language skills, and primary motor and perceptual abilities. Recovery from alcoholism is associated with a partial reversal of CNS deficits that occur in alcoholism. The reversal of deficits during recovery from alcoholism indicates that brain structure is capable of repair and restructuring in response to insult in adulthood. Indirect support of this repair model derives from studies of selective neuropsychological processes, structural and functional neuroimaging studies, and preclinical studies on degeneration and regeneration during the development of alcohol dependence and recovery from dependence. Genetics and brain regional specificity contribute to unique changes in neuropsychology and neuroanatomy in alcoholism and recovery. This symposium includes state-of-the-art presentations on changes that occur during active alcoholism as well as those that may occur during recovery-abstinence from alcohol dependence. Included are human neuroimaging and neuropsychological assessments, changes in human brain gene expression, allelic combinations of genes associated with alcohol dependence and preclinical studies investigating mechanisms of alcohol induced neurotoxicity, and neuroprogenetor cell expansion during recovery from alcohol dependence.
AB - This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October, 2004. Chronic alcoholism follows a fluctuating course, which provides a naturalistic experiment in vulnerability, resilience, and recovery of human neural systems in response to presence, absence, and history of the neurotoxic effects of alcoholism. Alcohol dependence is a progressive chronic disease that is associated with changes in neuroanatomy, neurophysiology, neural gene expression, psychology, and behavior. Specifically, alcohol dependence is characterized by a neuropsychological profile of mild to moderate impairment in executive functions, visuospatial abilities, and postural stability, together with relative sparing of declarative memory, language skills, and primary motor and perceptual abilities. Recovery from alcoholism is associated with a partial reversal of CNS deficits that occur in alcoholism. The reversal of deficits during recovery from alcoholism indicates that brain structure is capable of repair and restructuring in response to insult in adulthood. Indirect support of this repair model derives from studies of selective neuropsychological processes, structural and functional neuroimaging studies, and preclinical studies on degeneration and regeneration during the development of alcohol dependence and recovery from dependence. Genetics and brain regional specificity contribute to unique changes in neuropsychology and neuroanatomy in alcoholism and recovery. This symposium includes state-of-the-art presentations on changes that occur during active alcoholism as well as those that may occur during recovery-abstinence from alcohol dependence. Included are human neuroimaging and neuropsychological assessments, changes in human brain gene expression, allelic combinations of genes associated with alcohol dependence and preclinical studies investigating mechanisms of alcohol induced neurotoxicity, and neuroprogenetor cell expansion during recovery from alcohol dependence.
KW - Alcohol Dependence
KW - Neuroanatomy
KW - Neuroimaging
KW - Neuropsychology
KW - Recovery
UR - http://www.scopus.com/inward/record.url?scp=24144482734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24144482734&partnerID=8YFLogxK
U2 - 10.1097/01.alc.0000175013.50644.61
DO - 10.1097/01.alc.0000175013.50644.61
M3 - Article
C2 - 16156047
AN - SCOPUS:24144482734
VL - 29
SP - 1504
EP - 1513
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
SN - 0145-6008
IS - 8
ER -