Alcoholic neurobiology: Changes in dependence and recovery

Fulton T. Crews, Tracey Buckley, Peter R. Dodd, Gabriele Ende, Nina Foley, Clive Harper, Jun He, David Innes, El Wui Loh, Adolf Pfefferbaum, Jian Zou, Edith V. Sullivan

研究成果: 雜誌貢獻文章同行評審

109 引文 斯高帕斯(Scopus)

摘要

This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October, 2004. Chronic alcoholism follows a fluctuating course, which provides a naturalistic experiment in vulnerability, resilience, and recovery of human neural systems in response to presence, absence, and history of the neurotoxic effects of alcoholism. Alcohol dependence is a progressive chronic disease that is associated with changes in neuroanatomy, neurophysiology, neural gene expression, psychology, and behavior. Specifically, alcohol dependence is characterized by a neuropsychological profile of mild to moderate impairment in executive functions, visuospatial abilities, and postural stability, together with relative sparing of declarative memory, language skills, and primary motor and perceptual abilities. Recovery from alcoholism is associated with a partial reversal of CNS deficits that occur in alcoholism. The reversal of deficits during recovery from alcoholism indicates that brain structure is capable of repair and restructuring in response to insult in adulthood. Indirect support of this repair model derives from studies of selective neuropsychological processes, structural and functional neuroimaging studies, and preclinical studies on degeneration and regeneration during the development of alcohol dependence and recovery from dependence. Genetics and brain regional specificity contribute to unique changes in neuropsychology and neuroanatomy in alcoholism and recovery. This symposium includes state-of-the-art presentations on changes that occur during active alcoholism as well as those that may occur during recovery-abstinence from alcohol dependence. Included are human neuroimaging and neuropsychological assessments, changes in human brain gene expression, allelic combinations of genes associated with alcohol dependence and preclinical studies investigating mechanisms of alcohol induced neurotoxicity, and neuroprogenetor cell expansion during recovery from alcohol dependence.
原文英語
頁(從 - 到)1504-1513
頁數10
期刊Alcoholism: Clinical and Experimental Research
29
發行號8
DOIs
出版狀態已發佈 - 八月 2005
對外發佈

ASJC Scopus subject areas

  • 醫藥(雜項)
  • 毒理學
  • 精神病學和心理健康

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