Albumin batches and B19 parvovirus DNA

J. J. Lefrere, M. Mariotti, I. De la Croix, J. Lerable, M. Thauvin, T. Burnouf, G. Follea

研究成果: 雜誌貢獻文章同行評審

22 引文 斯高帕斯(Scopus)

摘要

Background: B19 parvovirus (B19) maybe transmitted iatrogenically by blood, and its prevalence in blood donations is estimated at 1 in 3,300 to 1 in 50,000. As a large number of blood donations make up the plasma pools used to produce plasma derivatives, even a virus as rare as B19 in a population of blood donors may result in the frequent contamination of plasma batches. The percentage of albumin batches containing B19 DNA has never been determined. Study Design and Methods: The presence of B19 DNA was investigated by a polymerase chain reaction assay (with a primer pair in the VP1 region) in a total of 12 and 17 batches of 4- and 20-percent albumin, respectively, from two different manufacturers. Results: No B19 DNA was detected in the batches tested. Conclusion: The current fractionation process used to obtain these albumin preparations is seen to allow the efficient degradation and/or elimination of B19.
原文英語
頁(從 - 到)389-391
頁數3
期刊Transfusion
35
發行號5
出版狀態已發佈 - 1995
對外發佈

ASJC Scopus subject areas

  • 免疫學
  • 血液學

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