摘要

Background: While effects of occupational and environmental air pollution exposure on inflammation-related cardiopulmonary impairment are well documented, the association linking long-term air pollution exposure and osteoporosis risk is still unclear. The aim of this study was to investigate effects of long-term air pollution exposure on the risk of osteoporosis in people with chronic obstructive pulmonary disease (COPD). Methods: We collected 70 retired workers’ data from the pulmonary outpatient unit of a medical center in Taiwan and air pollution data from the Taiwan Environmental Protection Administration. Associations of 1-year averaged criteria air pollutants [particulate matter with aerodynamic diameters <10 μm (PM10), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)] with the risk of osteoporosis were explored by generalized additive models. Effect modification by inhaled corticosteroids (ICS) usage was also assessed in the model. Results: After controlling for age, sex, body mass index, current smoking, drinking, ICS usage, six-minute walk distance, global initiative for chronic obstructive and smooth functions of interview date and yearly temperature, we observed that increased 1-year averaged NO2 was significantly associated with 45% higher odds of osteoporosis (odds ratio=1.451 [95% confidence interval=1.124 to 1.778]). Retired workers with ICS usage showed 44% higher odds of osteoporosis associated with increased NO2. Conclusions: The risk of developing osteoporosis among retired workers with COPD was positively associated with long-term exposure to 1-year averaged NO2. ICS usage can modify the effect of NO2 on osteoporosis risk.
原文英語
頁(從 - 到)167
期刊Occupational Medicine & Health Affairs
2
發行號3
DOIs
出版狀態已發佈 - 六月 2014

指紋

Air Pollution
Chronic Obstructive Pulmonary Disease
Osteoporosis
Adrenal Cortex Hormones
Taiwan
Nitrogen Dioxide
Sulfur Dioxide
Air Pollutants
Environmental Pollution
Particulate Matter
Ozone
Conservation of Natural Resources
Carbon Monoxide
Drinking
Body Mass Index
Outpatients
Smoking
Odds Ratio
Confidence Intervals
Interviews

Keywords

  • Air pollution
  • Long-term exposure
  • Osteoporosis
  • Chronic obstructive pulmonary disease

引用此文

@article{2cb0a18256e04c19914e849ae6a09a69,
title = "Air Pollution Exposure and Osteoporosis among Retired Workers with Chronic Obstructive Pulmonary Disease",
abstract = "Background: While effects of occupational and environmental air pollution exposure on inflammation-related cardiopulmonary impairment are well documented, the association linking long-term air pollution exposure and osteoporosis risk is still unclear. The aim of this study was to investigate effects of long-term air pollution exposure on the risk of osteoporosis in people with chronic obstructive pulmonary disease (COPD). Methods: We collected 70 retired workers’ data from the pulmonary outpatient unit of a medical center in Taiwan and air pollution data from the Taiwan Environmental Protection Administration. Associations of 1-year averaged criteria air pollutants [particulate matter with aerodynamic diameters <10 μm (PM10), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)] with the risk of osteoporosis were explored by generalized additive models. Effect modification by inhaled corticosteroids (ICS) usage was also assessed in the model. Results: After controlling for age, sex, body mass index, current smoking, drinking, ICS usage, six-minute walk distance, global initiative for chronic obstructive and smooth functions of interview date and yearly temperature, we observed that increased 1-year averaged NO2 was significantly associated with 45{\%} higher odds of osteoporosis (odds ratio=1.451 [95{\%} confidence interval=1.124 to 1.778]). Retired workers with ICS usage showed 44{\%} higher odds of osteoporosis associated with increased NO2. Conclusions: The risk of developing osteoporosis among retired workers with COPD was positively associated with long-term exposure to 1-year averaged NO2. ICS usage can modify the effect of NO2 on osteoporosis risk.",
keywords = "Air pollution, Long-term exposure, Osteoporosis, Chronic obstructive pulmonary disease, Air pollution, Long-term exposure, Osteoporosis, Chronic obstructive pulmonary disease",
author = "Kang-Yun Lee and Wen-Te Liu and Kuo, {Han Pin} and Wang, {Chun Hua} and Hsiao-Chi Chuang and Chen, {Tzu Tao} and Shu-Chuan Ho and Hsu, {Min Fang} and Kai-Jen Chuang",
year = "2014",
month = "6",
doi = "10.4172/2329-6879.1000167",
language = "English",
volume = "2",
pages = "167",
journal = "Occupational Medicine & Health Affairs",
issn = "2329-6879",
number = "3",

}

TY - JOUR

T1 - Air Pollution Exposure and Osteoporosis among Retired Workers with Chronic Obstructive Pulmonary Disease

AU - Lee, Kang-Yun

AU - Liu, Wen-Te

AU - Kuo, Han Pin

AU - Wang, Chun Hua

AU - Chuang, Hsiao-Chi

AU - Chen, Tzu Tao

AU - Ho, Shu-Chuan

AU - Hsu, Min Fang

AU - Chuang, Kai-Jen

PY - 2014/6

Y1 - 2014/6

N2 - Background: While effects of occupational and environmental air pollution exposure on inflammation-related cardiopulmonary impairment are well documented, the association linking long-term air pollution exposure and osteoporosis risk is still unclear. The aim of this study was to investigate effects of long-term air pollution exposure on the risk of osteoporosis in people with chronic obstructive pulmonary disease (COPD). Methods: We collected 70 retired workers’ data from the pulmonary outpatient unit of a medical center in Taiwan and air pollution data from the Taiwan Environmental Protection Administration. Associations of 1-year averaged criteria air pollutants [particulate matter with aerodynamic diameters <10 μm (PM10), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)] with the risk of osteoporosis were explored by generalized additive models. Effect modification by inhaled corticosteroids (ICS) usage was also assessed in the model. Results: After controlling for age, sex, body mass index, current smoking, drinking, ICS usage, six-minute walk distance, global initiative for chronic obstructive and smooth functions of interview date and yearly temperature, we observed that increased 1-year averaged NO2 was significantly associated with 45% higher odds of osteoporosis (odds ratio=1.451 [95% confidence interval=1.124 to 1.778]). Retired workers with ICS usage showed 44% higher odds of osteoporosis associated with increased NO2. Conclusions: The risk of developing osteoporosis among retired workers with COPD was positively associated with long-term exposure to 1-year averaged NO2. ICS usage can modify the effect of NO2 on osteoporosis risk.

AB - Background: While effects of occupational and environmental air pollution exposure on inflammation-related cardiopulmonary impairment are well documented, the association linking long-term air pollution exposure and osteoporosis risk is still unclear. The aim of this study was to investigate effects of long-term air pollution exposure on the risk of osteoporosis in people with chronic obstructive pulmonary disease (COPD). Methods: We collected 70 retired workers’ data from the pulmonary outpatient unit of a medical center in Taiwan and air pollution data from the Taiwan Environmental Protection Administration. Associations of 1-year averaged criteria air pollutants [particulate matter with aerodynamic diameters <10 μm (PM10), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)] with the risk of osteoporosis were explored by generalized additive models. Effect modification by inhaled corticosteroids (ICS) usage was also assessed in the model. Results: After controlling for age, sex, body mass index, current smoking, drinking, ICS usage, six-minute walk distance, global initiative for chronic obstructive and smooth functions of interview date and yearly temperature, we observed that increased 1-year averaged NO2 was significantly associated with 45% higher odds of osteoporosis (odds ratio=1.451 [95% confidence interval=1.124 to 1.778]). Retired workers with ICS usage showed 44% higher odds of osteoporosis associated with increased NO2. Conclusions: The risk of developing osteoporosis among retired workers with COPD was positively associated with long-term exposure to 1-year averaged NO2. ICS usage can modify the effect of NO2 on osteoporosis risk.

KW - Air pollution

KW - Long-term exposure

KW - Osteoporosis

KW - Chronic obstructive pulmonary disease

KW - Air pollution

KW - Long-term exposure

KW - Osteoporosis

KW - Chronic obstructive pulmonary disease

UR - http://www.esciencecentral.org/journals/air-pollution-exposure-and-osteoporosis-among-retired-workers-with-chronic-obstructive-pulmonary-disease-2329-6879.1000167.php?aid=27281

U2 - 10.4172/2329-6879.1000167

DO - 10.4172/2329-6879.1000167

M3 - Article

VL - 2

SP - 167

JO - Occupational Medicine & Health Affairs

JF - Occupational Medicine & Health Affairs

SN - 2329-6879

IS - 3

ER -