Aging modulates the substrate and triggers remodeling in atrial fibrillation

Yung Kuo Lin, Yi Ann Chen, Ting I. Lee, Yao Chang Chen, Shih Ann Chen, Yi Jen Chen

研究成果: 雜誌貢獻回顧型文獻

8 引文 斯高帕斯(Scopus)

摘要

Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.
原文英語
頁(從 - 到)1237-1244
頁數8
期刊Circulation Journal
82
發行號5
DOIs
出版狀態已發佈 - 一月 1 2018

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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