Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection

Chuan Mo Lee, Sheng Nan Lu, Chi Sin Changchien, Chau Ting Yeh, Tsung Teng Hsu, Jui-Hsiang Tang, Jing Houng Wang, Deng Yn Lin, Chao Long Chen, Wei Jen Chen

研究成果: 雜誌貢獻文章同行評審

157 引文 斯高帕斯(Scopus)

摘要

BACKGROUND. There are etiologic variations of hepatocellular carcinoma (HCC) in different geographic areas. Taiwan is a hyperendemic area for hepatitis B virus (HBV) infection. Hepatitis C virus (HCV) infection also plays an important role in HCC development in Taiwan. Identification of local HCV-endemic areas is important to keep HCV from spreading. This study investigated the etiologic variations of HCC in different geographic areas of Taiwan. METHODS. The authors evaluated the hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV) status of 284 patients (232 male, 52 female) with HCC. They also evaluated the gender ratio and mean age of these patients. RESULTS. The mean age of HBsAg positive patients was significantly lower than the mean age of HBsAg negative patients (52.6 ± 12.3 vs. 613 ± 11.2 years) (P < 0.05). The male-to-female ratio was 4.5:1 for all HCC patients, 7:1 for HBsAg positive HCC patients, and 2.8:1 for anti-HCV positive HCC patient. In Chaiyi County in southern Taiwan, the prevalence of anti-HCV in male HCC patients was 52%, significantly greater than that of Taiwan as a whole (27.6%) (P = 0.07). However, the prevalence of anti-HCV in male HCC patients in Taipei County in northern Taiwan was 8.7%, significantly less than that of Taiwan as a whole (P = 0.043). Of a total of 65 Chiayi- based HCC patients, 55.4% were anti-HCV positive and 46.2% were HBsAg positive. In the Chiayi area, results of multiple logistic regression showed that the HCC patients who were are 60 years or older or who were living in the city area both had highly HCV-related disease. CONCLUSIONS. The mean age of patients with HBV-related HCC was significantly lower than that of patients with non-HBV-related HCC. The male-to-female ratio for patients with HBV-related HCC was significantly higher than that of patients with HCV- related HCC. The authors identified an area of Taiwan in which HCV-related HCC was prevalent.

原文英語
頁(從 - 到)1143-1150
頁數8
期刊Cancer
86
發行號7
DOIs
出版狀態已發佈 - 十月 1 1999
對外發佈

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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