Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients

Jin Biou Chang, Nain Feng Chu, Jhu Ting Syu, An Tsz Hsieh, Yi Ren Hung

研究成果: 雜誌貢獻文章同行評審

26 引文 斯高帕斯(Scopus)

摘要

Objectives. To evaluate the association between AGEs and atherosclerotic lipid profiles among aging diabetic patients in Taiwan. Design and Methods. After age and gender matching, we selected 207 diabetic subjects and 174 diabetic subjects with proteinuria. Lipid profiles, including total cholesterol (TC), triglycerides (TG), high density cholesterol-lipoprotein (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using standard methods. AGEs were measured with the immunoassay method. Results: In general, males were heavier; however, females had higher AGEs, fasting glucose (GLU), TC, HDL-C and LDL-C levels than males, and had higher TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C ratios compared to males. AGEs were more strongly correlated with TG levels and TCL/LDL-C, LDL-C/HDL-C and TG/HDL-C ratios when compared to glucose or hemoglobin A1c. Subjects had higher AGEs levels (≧ 2.0 AU) with more adverse lipid profiles. Conclusion: AGEs seem to be a good biomarker to evaluate the association between diabetes and atherosclerotic disorders in aging diabetes.
原文英語
文章編號228
期刊Lipids in Health and Disease
10
DOIs
出版狀態已發佈 - 2011

ASJC Scopus subject areas

  • 臨床生物化學
  • 生物化學(醫學)
  • 內分泌學、糖尿病和代謝
  • 內分泌

指紋

深入研究「Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients」主題。共同形成了獨特的指紋。

引用此