Adsorption of peptides to poly(D,L-lactide-co-glycolide): 2. Effect of solution properties on the adsorption

Tsuimin Tsai, Rahul C. Mehta, Patrick P. DeLuca

研究成果: 雜誌貢獻文章

30 引文 斯高帕斯(Scopus)

摘要

The effect of pH, ionic strength, polarity and temperature on the adsorption of three peptides to poly(D,L-lactide-co-glycolide) (PLGA) was evaluated. Maximum adsorption was found near the pi of the peptide for salmon calcitonin (sCT), triptorelin (DP) and a peptide comprising the 8-22 amino acid portion of sCT. For sCT, almost no adsorption was observed at pH <6 while there was complete depletion at pH 10. Increase in NaCl concentration enhanced the adsorption of sCT and DP. The dependency on solvent ionic strength and polarity suggested that hydrophobic interactions were playing an important role in the adsorption process. The net adsorption of sCT and DP was greater at 22°C than at 4°C or 37°C.

原文英語
頁(從 - 到)43-52
頁數10
期刊International Journal of Pharmaceutics
127
發行號1
DOIs
出版狀態已發佈 - 一月 15 1996

ASJC Scopus subject areas

  • Pharmaceutical Science

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