Adsorption of peptides to poly(D,L-lactide-co-glycolide): 1. Effect of physical factors on the adsorption

Tsuimin Tsai, Rahul C. Mehta, Patrick P. DeLuca

研究成果: 雜誌貢獻文章同行評審

33 引文 斯高帕斯(Scopus)

摘要

Four peptides, salmon calcitonin (sCT), the 8-22 amino acid portion of sCT (CT15), an LHRH superagonist, triptorelin (DP) and a somatostatin analogue (RC160) were studied for adsorption to poly(D,L-lactide-co-glycolide) (PLGA) as a function of peptide and polymer concentration. The adsorption of sCT and DP to the polymer showed a primary transient-equilibrium followed by a more rapid and extensive adsorption without reaching a concentration plateau for sCT which occurred earlier with higher peptide concentration. The amount of adsorption for CT15 was much lower than that for sCT and DP and RC160 showed no adsorption. Adsorption isotherms of sCT and DP were fitted to a Langmuir-type of relationship and the monolayer concentration was close to that observed in the kinetic studies or that calculated by the theoretical approach.

原文英語
頁(從 - 到)31-42
頁數12
期刊International Journal of Pharmaceutics
127
發行號1
DOIs
出版狀態已發佈 - 一月 15 1996

ASJC Scopus subject areas

  • 藥學科學

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