Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

K. M. Tewey, T. C. Rowe, L. Yang, B. D. Halligan, Leroy-Fong Liu

研究成果: 雜誌貢獻文章

1194 引文 斯高帕斯(Scopus)

摘要

Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the molecular basis for its antitumor activity is unknown. Similar to a number of intercalative antitumor drugs and nonintercalative epipodophyllotoxins (VP-16 and VM-26), adriamycin has been shown to induce single- and double-strand breaks in DNA. These strand breaks are unusual because a cavalently bound protein appears to be associated with each broken phosphodiester bond. In studies in vitro, mammalian DNA topoisomerase II mediates DNA damage by adriamycin and other related antitumor drugs.

原文英語
頁(從 - 到)466-468
頁數3
期刊Science
226
發行號4673
出版狀態已發佈 - 1984
對外發佈Yes

ASJC Scopus subject areas

  • General

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  • 引用此

    Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., & Liu, L-F. (1984). Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science, 226(4673), 466-468.