Adjuvant tamoxifen influences the lipid profile in breast cancer patients

Che Lin, Li Sheng Chen, Shou Jen Kuo, Dar Ren Chen

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

Background: Currently there is a debate regarding whether tamoxifen used in breast cancer has an impact on lipid profiles. The aim of this study was to determine whether tamoxifen has an impact on the serum lipid profile in Taiwanese women. Patients and Methods: Data of 109 patients were collected from the routine clinical follow-up for women with hormone receptor-positive breast cancer who were treated between July 2005 and March 2008. These patients were divided into 2 subgroups, based on their tumor grade and lymph node status. Subgroup 1 patients had tumor grade I/II and a negative lymph node status. Those patients with tumor grade III or a positive lymph node status were defined as subgroup 2. Results: In the 109 patients, the mean serum total cholesterol (TC) levels after tamoxifen treatment, as well as the serum low-density lipoprotein cholesterol (LDL-C) levels, were lower than the baseline levels, with statistically significant differences. Treatment with tamoxifen lowered the serum TC and LDL-C levels in both subgroups. Conclusions: The results indicate that tamoxifen has an impact on the serum lipid profile of breast cancer patients in Taiwan. Physicians should follow up the lipid profile in these patients.
原文英語
頁(從 - 到)35-39
頁數5
期刊Breast Care
9
發行號1
DOIs
出版狀態已發佈 - 2014

    指紋

ASJC Scopus subject areas

  • Surgery
  • Oncology

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