Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Hong Jian Wei, Rong Zeng, Jui Hua Lu, Wen-FuThomas Lai, Wei Hong Chen, Hen Yu Liu, Ya Ting Chang, Win Ping Deng

研究成果: 雜誌貢獻文章

34 引文 (Scopus)

摘要

Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.
原文英語
頁(從 - 到)7713-7726
頁數14
期刊Oncotarget
6
發行號10
出版狀態已發佈 - 2015

指紋

Neoplastic Stem Cells
Interleukin-6
Stem Cells
Growth
Neoplasms
Multipotent Stem Cells
Coculture Techniques
Colonic Neoplasms
Breast Neoplasms
Genes

ASJC Scopus subject areas

  • Oncology

引用此文

Wei, H. J., Zeng, R., Lu, J. H., Lai, W-F., Chen, W. H., Liu, H. Y., ... Deng, W. P. (2015). Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. Oncotarget, 6(10), 7713-7726.

Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. / Wei, Hong Jian; Zeng, Rong; Lu, Jui Hua; Lai, Wen-FuThomas; Chen, Wei Hong; Liu, Hen Yu; Chang, Ya Ting; Deng, Win Ping.

於: Oncotarget, 卷 6, 編號 10, 2015, p. 7713-7726.

研究成果: 雜誌貢獻文章

Wei, HJ, Zeng, R, Lu, JH, Lai, W-F, Chen, WH, Liu, HY, Chang, YT & Deng, WP 2015, 'Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production', Oncotarget, 卷 6, 編號 10, 頁 7713-7726.
Wei HJ, Zeng R, Lu JH, Lai W-F, Chen WH, Liu HY 等. Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. Oncotarget. 2015;6(10):7713-7726.
Wei, Hong Jian ; Zeng, Rong ; Lu, Jui Hua ; Lai, Wen-FuThomas ; Chen, Wei Hong ; Liu, Hen Yu ; Chang, Ya Ting ; Deng, Win Ping. / Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. 於: Oncotarget. 2015 ; 卷 6, 編號 10. 頁 7713-7726.
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