Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Hong Jian Wei, Rong Zeng, Jui Hua Lu, Wen-FuThomas Lai, Wei Hong Chen, Hen Yu Liu, Ya Ting Chang, Win Ping Deng

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42 引文 斯高帕斯(Scopus)

摘要

Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.
原文英語
頁(從 - 到)7713-7726
頁數14
期刊Oncotarget
6
發行號10
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • Oncology

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