Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome

Kok Min Seow, Chi Chang Juan, Low Tone Ho, Yung Pei Hsu, Yu Hung Lin, Lee Wen Huang, Jiann Loung Hwang

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

BACKGROUND: The aim of this study was to investigate serum and adipocyte mRNA expression of resistin in lean and obese women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). METHODS: Adipose tissue obtained from 12 women with PCOS (six obese and six lean, body mass index > 27 kg m-1 as threshold point) before and after LOE was analysed. Gene expression of resistin was measured by semi-quantitative RT-PCR. Ten lean, age-matched healthy women served as controls. RESULTS: Both lean and obese women with PCOS had significantly higher fasting and 2 h insulin and homeostasis model insulin resistance index (HOMAIR) values and lower fasting glucose-to-insulin ratios (G0/I0) than did the controls. The serum levels of glucose and insulin and HOMAIR were significantly decreased, and the G0/I0 ratio was significantly increased 3 months after LOE. No difference was found in serum resistin levels between controls and either obese or lean women with PCOS before LOE, nor between PCOS patients before and after LOE. However, resistin mRNA expression levels in both lean and obese women with PCOS before LOE were significantly higher than that in controls and were decreased significantly after LOE back to control levels. CONCLUSION: Local resistin activity may be actively involved in the pathogenesis of PCOS. LOE reduces insulin resistance and down-regulates resistin mRNA expression in lean and obese women with PCOS.
原文英語
頁(從 - 到)1100-1106
頁數7
期刊Human Reproduction
22
發行號4
DOIs
出版狀態已發佈 - 4月 2007

ASJC Scopus subject areas

  • 生理學
  • 發展生物學
  • 婦產科
  • 生殖醫學

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