Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications

Bou Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng Chou Tsai, Rajni Dubey, Win Ping Deng, Hong Jian Wei

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.
原文英語
文章編號7806435
期刊Journal of Diabetes Research
2018
DOIs
出版狀態已發佈 - 一月 1 2018

指紋

Diabetes Complications
Diabetes Mellitus
Stem Cells
Multipotent Stem Cells
Pluripotent Stem Cells
Therapeutics
Cell- and Tissue-Based Therapy
Type 1 Diabetes Mellitus
Hyperglycemia
Type 2 Diabetes Mellitus
Insulin Resistance
Regeneration
Oxidative Stress
Transplantation
Insulin
Morbidity
Mortality
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

引用此文

Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications. / Peng, Bou Yue; Dubey, Navneet Kumar; Mishra, Viraj Krishna; Tsai, Feng Chou; Dubey, Rajni; Deng, Win Ping; Wei, Hong Jian.

於: Journal of Diabetes Research, 卷 2018, 7806435, 01.01.2018.

研究成果: 雜誌貢獻文章

Peng, Bou Yue ; Dubey, Navneet Kumar ; Mishra, Viraj Krishna ; Tsai, Feng Chou ; Dubey, Rajni ; Deng, Win Ping ; Wei, Hong Jian. / Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications. 於: Journal of Diabetes Research. 2018 ; 卷 2018.
@article{539b97a887cf4012a4be732a0963e5a9,
title = "Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications",
abstract = "High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.",
author = "Peng, {Bou Yue} and Dubey, {Navneet Kumar} and Mishra, {Viraj Krishna} and Tsai, {Feng Chou} and Rajni Dubey and Deng, {Win Ping} and Wei, {Hong Jian}",
year = "2018",
month = "1",
day = "1",
doi = "10.1155/2018/7806435",
language = "English",
volume = "2018",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications

AU - Peng, Bou Yue

AU - Dubey, Navneet Kumar

AU - Mishra, Viraj Krishna

AU - Tsai, Feng Chou

AU - Dubey, Rajni

AU - Deng, Win Ping

AU - Wei, Hong Jian

PY - 2018/1/1

Y1 - 2018/1/1

N2 - High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.

AB - High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.

UR - http://www.scopus.com/inward/record.url?scp=85052060175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052060175&partnerID=8YFLogxK

U2 - 10.1155/2018/7806435

DO - 10.1155/2018/7806435

M3 - Article

VL - 2018

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 7806435

ER -