Acyltransferases for secreted signalling proteins (Review)

Shu Chun Chang, Anthony I. Magee

研究成果: 雜誌貢獻回顧型文獻

31 引文 斯高帕斯(Scopus)

摘要

Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.
原文英語
頁(從 - 到)104-113
頁數10
期刊Molecular Membrane Biology
26
發行號1-2
DOIs
出版狀態已發佈 - 一月 2009
對外發佈Yes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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