摘要
Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.
原文 | 英語 |
---|---|
頁(從 - 到) | 696-699 |
頁數 | 4 |
期刊 | Annals of Hematology |
卷 | 79 |
發行號 | 12 |
DOIs | |
出版狀態 | 已發佈 - 2000 |
對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Hematology
引用此文
Acute respiratory distress syndrome following intrathecal methotrexate administration : A case report and review of literature. / Dai, M. S.; Ho, C. L.; Chen, Y. C.; Kao, W. Y.; Chao, T. Y.
於: Annals of Hematology, 卷 79, 編號 12, 2000, p. 696-699.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Acute respiratory distress syndrome following intrathecal methotrexate administration
T2 - A case report and review of literature
AU - Dai, M. S.
AU - Ho, C. L.
AU - Chen, Y. C.
AU - Kao, W. Y.
AU - Chao, T. Y.
PY - 2000
Y1 - 2000
N2 - Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.
AB - Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.
KW - Acute respiratory distress syndrome
KW - Intrathecal
KW - Methotrexate
UR - http://www.scopus.com/inward/record.url?scp=0034533566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034533566&partnerID=8YFLogxK
U2 - 10.1007/s002770000217
DO - 10.1007/s002770000217
M3 - Article
C2 - 11195008
AN - SCOPUS:0034533566
VL - 79
SP - 696
EP - 699
JO - Annals of Hematology
JF - Annals of Hematology
SN - 0939-5555
IS - 12
ER -