Acute respiratory distress syndrome following intrathecal methotrexate administration: A case report and review of literature

M. S. Dai, C. L. Ho, Y. C. Chen, W. Y. Kao, T. Y. Chao

研究成果: 雜誌貢獻文章

16 引文 (Scopus)

摘要

Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

原文英語
頁(從 - 到)696-699
頁數4
期刊Annals of Hematology
79
發行號12
DOIs
出版狀態已發佈 - 2000
對外發佈Yes

指紋

Adult Respiratory Distress Syndrome
Methotrexate
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lung
Adrenal Cortex Hormones
Cranial Irradiation
Spinal Injections
Respiratory Insufficiency
Central Nervous System
Therapeutics

ASJC Scopus subject areas

  • Hematology

引用此文

Acute respiratory distress syndrome following intrathecal methotrexate administration : A case report and review of literature. / Dai, M. S.; Ho, C. L.; Chen, Y. C.; Kao, W. Y.; Chao, T. Y.

於: Annals of Hematology, 卷 79, 編號 12, 2000, p. 696-699.

研究成果: 雜誌貢獻文章

@article{257fec6937784c8387ec876de571d54a,
title = "Acute respiratory distress syndrome following intrathecal methotrexate administration: A case report and review of literature",
abstract = "Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.",
keywords = "Acute respiratory distress syndrome, Intrathecal, Methotrexate",
author = "Dai, {M. S.} and Ho, {C. L.} and Chen, {Y. C.} and Kao, {W. Y.} and Chao, {T. Y.}",
year = "2000",
doi = "10.1007/s002770000217",
language = "English",
volume = "79",
pages = "696--699",
journal = "Annals of Hematology",
issn = "0939-5555",
publisher = "Springer Verlag",
number = "12",

}

TY - JOUR

T1 - Acute respiratory distress syndrome following intrathecal methotrexate administration

T2 - A case report and review of literature

AU - Dai, M. S.

AU - Ho, C. L.

AU - Chen, Y. C.

AU - Kao, W. Y.

AU - Chao, T. Y.

PY - 2000

Y1 - 2000

N2 - Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

AB - Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

KW - Acute respiratory distress syndrome

KW - Intrathecal

KW - Methotrexate

UR - http://www.scopus.com/inward/record.url?scp=0034533566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034533566&partnerID=8YFLogxK

U2 - 10.1007/s002770000217

DO - 10.1007/s002770000217

M3 - Article

C2 - 11195008

AN - SCOPUS:0034533566

VL - 79

SP - 696

EP - 699

JO - Annals of Hematology

JF - Annals of Hematology

SN - 0939-5555

IS - 12

ER -