Acute myocardial infarction in patients with atrial fibrillation with a CHA2DS2-VASc score of 0 or 1: a nationwide cohort study

Tze Fan Chao, Yen Chang Huang, Chia Jen Liu, Su Jung Chen, Kang Ling Wang, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Ta Chuan Tuan, Tzeng Ji Chen, Ming Hsiung Hsieh, Gregory Y H Lip, Shih Ann Chen

研究成果: 雜誌貢獻文章

34 引文 (Scopus)

摘要

BACKGROUND: The risk of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF) with a CHA2DS2-VASc score of 0 (for men) or 1 (for women) has not been previously investigated.

OBJECTIVE: The objective of the present study was to compare the risk of AMI in AF and non-AF subjects with a low (0 or 1) CHA2DS2-VASc score.

METHODS: By using the National Health Insurance Research Database in Taiwan, we identified 7254 men with AF (with a CHA2DS2-VASc score of 0) and 4860 women with AF (with a CHA2DS2-VASc score of 1). For each study patient, 1 age-, sex-, and CHA2DS2-VASc score-matched subject without AF was randomly selected to constitute the control group (n = 12,114). The clinical end point was the occurrence of AMI.

RESULTS: During a mean follow-up period of 5.7 ± 3.6 years, 258 patients (1.1%) suffered an AMI, with an annual incidence of 0.29% and 0.10% for patients with and without AF. AF was an independent risk factor of AMI, with an adjusted hazard ratio (HR) of 2.93 (95% confidence interval 2.21-3.87; P <.001). The risk of AMI was higher in men with AF than in women with AF, with a hazard ratio of 2.24 (95% confidence interval 1.61-3.11; P <.001) after adjustment for age and other comorbidities.

CONCLUSION: In patients with a CHA2DS2-VASc score of 0 or 1, AF was an independent risk factor of AMI. The risk of AMI was higher in men with AF than in women with AF. Cardiovascular risk prevention should be performed as part of the holistic management of AF to minimize the risks of AMI associated with AF.

原文英語
頁(從 - 到)1941-1947
頁數7
期刊Heart Rhythm
11
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2014

指紋

Atrial Fibrillation
Cohort Studies
Myocardial Infarction
Confidence Intervals
National Health Programs
Taiwan
Comorbidity
Databases

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Chao, T. F., Huang, Y. C., Liu, C. J., Chen, S. J., Wang, K. L., Lin, Y. J., ... Chen, S. A. (2014). Acute myocardial infarction in patients with atrial fibrillation with a CHA2DS2-VASc score of 0 or 1: a nationwide cohort study. Heart Rhythm, 11(11), 1941-1947. https://doi.org/10.1016/j.hrthm.2014.08.003

Acute myocardial infarction in patients with atrial fibrillation with a CHA2DS2-VASc score of 0 or 1 : a nationwide cohort study. / Chao, Tze Fan; Huang, Yen Chang; Liu, Chia Jen; Chen, Su Jung; Wang, Kang Ling; Lin, Yenn Jiang; Chang, Shih Lin; Lo, Li Wei; Hu, Yu Feng; Tuan, Ta Chuan; Chen, Tzeng Ji; Hsieh, Ming Hsiung; Lip, Gregory Y H; Chen, Shih Ann.

於: Heart Rhythm, 卷 11, 編號 11, 01.11.2014, p. 1941-1947.

研究成果: 雜誌貢獻文章

Chao, TF, Huang, YC, Liu, CJ, Chen, SJ, Wang, KL, Lin, YJ, Chang, SL, Lo, LW, Hu, YF, Tuan, TC, Chen, TJ, Hsieh, MH, Lip, GYH & Chen, SA 2014, 'Acute myocardial infarction in patients with atrial fibrillation with a CHA2DS2-VASc score of 0 or 1: a nationwide cohort study', Heart Rhythm, 卷 11, 編號 11, 頁 1941-1947. https://doi.org/10.1016/j.hrthm.2014.08.003
Chao, Tze Fan ; Huang, Yen Chang ; Liu, Chia Jen ; Chen, Su Jung ; Wang, Kang Ling ; Lin, Yenn Jiang ; Chang, Shih Lin ; Lo, Li Wei ; Hu, Yu Feng ; Tuan, Ta Chuan ; Chen, Tzeng Ji ; Hsieh, Ming Hsiung ; Lip, Gregory Y H ; Chen, Shih Ann. / Acute myocardial infarction in patients with atrial fibrillation with a CHA2DS2-VASc score of 0 or 1 : a nationwide cohort study. 於: Heart Rhythm. 2014 ; 卷 11, 編號 11. 頁 1941-1947.
@article{0f27dac0d0c241548fce9933268a27a6,
title = "Acute myocardial infarction in patients with atrial fibrillation with a CHA2DS2-VASc score of 0 or 1: a nationwide cohort study",
abstract = "BACKGROUND: The risk of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF) with a CHA2DS2-VASc score of 0 (for men) or 1 (for women) has not been previously investigated.OBJECTIVE: The objective of the present study was to compare the risk of AMI in AF and non-AF subjects with a low (0 or 1) CHA2DS2-VASc score.METHODS: By using the National Health Insurance Research Database in Taiwan, we identified 7254 men with AF (with a CHA2DS2-VASc score of 0) and 4860 women with AF (with a CHA2DS2-VASc score of 1). For each study patient, 1 age-, sex-, and CHA2DS2-VASc score-matched subject without AF was randomly selected to constitute the control group (n = 12,114). The clinical end point was the occurrence of AMI.RESULTS: During a mean follow-up period of 5.7 ± 3.6 years, 258 patients (1.1{\%}) suffered an AMI, with an annual incidence of 0.29{\%} and 0.10{\%} for patients with and without AF. AF was an independent risk factor of AMI, with an adjusted hazard ratio (HR) of 2.93 (95{\%} confidence interval 2.21-3.87; P <.001). The risk of AMI was higher in men with AF than in women with AF, with a hazard ratio of 2.24 (95{\%} confidence interval 1.61-3.11; P <.001) after adjustment for age and other comorbidities.CONCLUSION: In patients with a CHA2DS2-VASc score of 0 or 1, AF was an independent risk factor of AMI. The risk of AMI was higher in men with AF than in women with AF. Cardiovascular risk prevention should be performed as part of the holistic management of AF to minimize the risks of AMI associated with AF.",
keywords = "Atrial fibrillation, CHA(2)DS(2)-VASc score, Gender, Myocardial infarction, Subclinical atherosclerosis",
author = "Chao, {Tze Fan} and Huang, {Yen Chang} and Liu, {Chia Jen} and Chen, {Su Jung} and Wang, {Kang Ling} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Lo, {Li Wei} and Hu, {Yu Feng} and Tuan, {Ta Chuan} and Chen, {Tzeng Ji} and Hsieh, {Ming Hsiung} and Lip, {Gregory Y H} and Chen, {Shih Ann}",
year = "2014",
month = "11",
day = "1",
doi = "10.1016/j.hrthm.2014.08.003",
language = "English",
volume = "11",
pages = "1941--1947",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "11",

}

TY - JOUR

T1 - Acute myocardial infarction in patients with atrial fibrillation with a CHA2DS2-VASc score of 0 or 1

T2 - a nationwide cohort study

AU - Chao, Tze Fan

AU - Huang, Yen Chang

AU - Liu, Chia Jen

AU - Chen, Su Jung

AU - Wang, Kang Ling

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Tuan, Ta Chuan

AU - Chen, Tzeng Ji

AU - Hsieh, Ming Hsiung

AU - Lip, Gregory Y H

AU - Chen, Shih Ann

PY - 2014/11/1

Y1 - 2014/11/1

N2 - BACKGROUND: The risk of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF) with a CHA2DS2-VASc score of 0 (for men) or 1 (for women) has not been previously investigated.OBJECTIVE: The objective of the present study was to compare the risk of AMI in AF and non-AF subjects with a low (0 or 1) CHA2DS2-VASc score.METHODS: By using the National Health Insurance Research Database in Taiwan, we identified 7254 men with AF (with a CHA2DS2-VASc score of 0) and 4860 women with AF (with a CHA2DS2-VASc score of 1). For each study patient, 1 age-, sex-, and CHA2DS2-VASc score-matched subject without AF was randomly selected to constitute the control group (n = 12,114). The clinical end point was the occurrence of AMI.RESULTS: During a mean follow-up period of 5.7 ± 3.6 years, 258 patients (1.1%) suffered an AMI, with an annual incidence of 0.29% and 0.10% for patients with and without AF. AF was an independent risk factor of AMI, with an adjusted hazard ratio (HR) of 2.93 (95% confidence interval 2.21-3.87; P <.001). The risk of AMI was higher in men with AF than in women with AF, with a hazard ratio of 2.24 (95% confidence interval 1.61-3.11; P <.001) after adjustment for age and other comorbidities.CONCLUSION: In patients with a CHA2DS2-VASc score of 0 or 1, AF was an independent risk factor of AMI. The risk of AMI was higher in men with AF than in women with AF. Cardiovascular risk prevention should be performed as part of the holistic management of AF to minimize the risks of AMI associated with AF.

AB - BACKGROUND: The risk of acute myocardial infarction (AMI) in patients with atrial fibrillation (AF) with a CHA2DS2-VASc score of 0 (for men) or 1 (for women) has not been previously investigated.OBJECTIVE: The objective of the present study was to compare the risk of AMI in AF and non-AF subjects with a low (0 or 1) CHA2DS2-VASc score.METHODS: By using the National Health Insurance Research Database in Taiwan, we identified 7254 men with AF (with a CHA2DS2-VASc score of 0) and 4860 women with AF (with a CHA2DS2-VASc score of 1). For each study patient, 1 age-, sex-, and CHA2DS2-VASc score-matched subject without AF was randomly selected to constitute the control group (n = 12,114). The clinical end point was the occurrence of AMI.RESULTS: During a mean follow-up period of 5.7 ± 3.6 years, 258 patients (1.1%) suffered an AMI, with an annual incidence of 0.29% and 0.10% for patients with and without AF. AF was an independent risk factor of AMI, with an adjusted hazard ratio (HR) of 2.93 (95% confidence interval 2.21-3.87; P <.001). The risk of AMI was higher in men with AF than in women with AF, with a hazard ratio of 2.24 (95% confidence interval 1.61-3.11; P <.001) after adjustment for age and other comorbidities.CONCLUSION: In patients with a CHA2DS2-VASc score of 0 or 1, AF was an independent risk factor of AMI. The risk of AMI was higher in men with AF than in women with AF. Cardiovascular risk prevention should be performed as part of the holistic management of AF to minimize the risks of AMI associated with AF.

KW - Atrial fibrillation

KW - CHA(2)DS(2)-VASc score

KW - Gender

KW - Myocardial infarction

KW - Subclinical atherosclerosis

UR - http://www.scopus.com/inward/record.url?scp=84930926059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930926059&partnerID=8YFLogxK

U2 - 10.1016/j.hrthm.2014.08.003

DO - 10.1016/j.hrthm.2014.08.003

M3 - Article

C2 - 25101483

AN - SCOPUS:84930926059

VL - 11

SP - 1941

EP - 1947

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 11

ER -