Acute Appendicitis in Patients with End-Stage Renal Disease

Pei-Wen Chao, Shuo Ming Ou, Yung Tai Chen, Yi Jung Lee, Feng Ming Wang, Chia Jen Liu, Wu Chang Yang, Tzeng Ji Chen, Tzen-Wen Chen, Szu Yuan Li

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

Background: Acute appendicitis in patients with end-stage renal disease (ESRD) poses a diagnostic challenge. Delayed surgery can contribute to higher morbidity and mortality rates. However, few studies have evaluated this disease among ESRD patients. Our study focused on the lack of data on the incidence and risk factors of acute appendicitis among ESRD patients and compared the outcomes in patients who underwent different dialysis modalities. Methods: This national survey was conducted between 1997 and 2005 and included ESRD patients identified from the Taiwan National Health Insurance database. The incidence rate of acute appendicitis in ESRD patients was compared with that in randomly selected age-, sex-, and Charlson comorbidity score-matched non-dialysis controls. A Cox regression hazard model was used to identify risk factors. Results: Among 59,781 incident ESRD patients, matched one-to-one with controls, there were 328 events of acute appendicitis. The incidence rate of 16.9 per 10,000 person-years in the ESRD cohort was higher than that in the control cohort (p = 0.003). The independent risk factors were atrial fibrillation (hazard ratio [HR], 2.08), severe liver disease (HR, 1.74), diabetes mellitus (HR, 1.58), and hemodialysis (HR, 1.74). Compared with the control cohort, subsequent perforation and mortality rates of acute appendicitis were also higher in the ESRD cohorts. There was no effect of dialysis modality on the patient outcomes. Conclusions: ESRD patients had a higher risk for acute appendicitis and poorer outcomes than non-dialysis populations. A careful examination of ESRD patients presenting with atypical abdominal pain to avoid misdiagnosis is extremely important to prevent delayed surgery.
原文英語
頁(從 - 到)1940-1946
頁數7
期刊Journal of Gastrointestinal Surgery
16
發行號10
DOIs
出版狀態已發佈 - 九月 2012

指紋

Appendicitis
Chronic Kidney Failure
Dialysis
Incidence
Mortality
National Health Programs
Diagnostic Errors
Taiwan
Proportional Hazards Models
Atrial Fibrillation
Abdominal Pain
Renal Dialysis
Comorbidity
Liver Diseases
Diabetes Mellitus
Databases
Morbidity

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

引用此文

Chao, P-W., Ou, S. M., Chen, Y. T., Lee, Y. J., Wang, F. M., Liu, C. J., ... Li, S. Y. (2012). Acute Appendicitis in Patients with End-Stage Renal Disease. Journal of Gastrointestinal Surgery, 16(10), 1940-1946. https://doi.org/10.1007/s11605-012-1961-z

Acute Appendicitis in Patients with End-Stage Renal Disease. / Chao, Pei-Wen; Ou, Shuo Ming; Chen, Yung Tai; Lee, Yi Jung; Wang, Feng Ming; Liu, Chia Jen; Yang, Wu Chang; Chen, Tzeng Ji; Chen, Tzen-Wen; Li, Szu Yuan.

於: Journal of Gastrointestinal Surgery, 卷 16, 編號 10, 09.2012, p. 1940-1946.

研究成果: 雜誌貢獻文章

Chao, P-W, Ou, SM, Chen, YT, Lee, YJ, Wang, FM, Liu, CJ, Yang, WC, Chen, TJ, Chen, T-W & Li, SY 2012, 'Acute Appendicitis in Patients with End-Stage Renal Disease', Journal of Gastrointestinal Surgery, 卷 16, 編號 10, 頁 1940-1946. https://doi.org/10.1007/s11605-012-1961-z
Chao, Pei-Wen ; Ou, Shuo Ming ; Chen, Yung Tai ; Lee, Yi Jung ; Wang, Feng Ming ; Liu, Chia Jen ; Yang, Wu Chang ; Chen, Tzeng Ji ; Chen, Tzen-Wen ; Li, Szu Yuan. / Acute Appendicitis in Patients with End-Stage Renal Disease. 於: Journal of Gastrointestinal Surgery. 2012 ; 卷 16, 編號 10. 頁 1940-1946.
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abstract = "Background: Acute appendicitis in patients with end-stage renal disease (ESRD) poses a diagnostic challenge. Delayed surgery can contribute to higher morbidity and mortality rates. However, few studies have evaluated this disease among ESRD patients. Our study focused on the lack of data on the incidence and risk factors of acute appendicitis among ESRD patients and compared the outcomes in patients who underwent different dialysis modalities. Methods: This national survey was conducted between 1997 and 2005 and included ESRD patients identified from the Taiwan National Health Insurance database. The incidence rate of acute appendicitis in ESRD patients was compared with that in randomly selected age-, sex-, and Charlson comorbidity score-matched non-dialysis controls. A Cox regression hazard model was used to identify risk factors. Results: Among 59,781 incident ESRD patients, matched one-to-one with controls, there were 328 events of acute appendicitis. The incidence rate of 16.9 per 10,000 person-years in the ESRD cohort was higher than that in the control cohort (p = 0.003). The independent risk factors were atrial fibrillation (hazard ratio [HR], 2.08), severe liver disease (HR, 1.74), diabetes mellitus (HR, 1.58), and hemodialysis (HR, 1.74). Compared with the control cohort, subsequent perforation and mortality rates of acute appendicitis were also higher in the ESRD cohorts. There was no effect of dialysis modality on the patient outcomes. Conclusions: ESRD patients had a higher risk for acute appendicitis and poorer outcomes than non-dialysis populations. A careful examination of ESRD patients presenting with atypical abdominal pain to avoid misdiagnosis is extremely important to prevent delayed surgery.",
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author = "Pei-Wen Chao and Ou, {Shuo Ming} and Chen, {Yung Tai} and Lee, {Yi Jung} and Wang, {Feng Ming} and Liu, {Chia Jen} and Yang, {Wu Chang} and Chen, {Tzeng Ji} and Tzen-Wen Chen and Li, {Szu Yuan}",
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AU - Chao, Pei-Wen

AU - Ou, Shuo Ming

AU - Chen, Yung Tai

AU - Lee, Yi Jung

AU - Wang, Feng Ming

AU - Liu, Chia Jen

AU - Yang, Wu Chang

AU - Chen, Tzeng Ji

AU - Chen, Tzen-Wen

AU - Li, Szu Yuan

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N2 - Background: Acute appendicitis in patients with end-stage renal disease (ESRD) poses a diagnostic challenge. Delayed surgery can contribute to higher morbidity and mortality rates. However, few studies have evaluated this disease among ESRD patients. Our study focused on the lack of data on the incidence and risk factors of acute appendicitis among ESRD patients and compared the outcomes in patients who underwent different dialysis modalities. Methods: This national survey was conducted between 1997 and 2005 and included ESRD patients identified from the Taiwan National Health Insurance database. The incidence rate of acute appendicitis in ESRD patients was compared with that in randomly selected age-, sex-, and Charlson comorbidity score-matched non-dialysis controls. A Cox regression hazard model was used to identify risk factors. Results: Among 59,781 incident ESRD patients, matched one-to-one with controls, there were 328 events of acute appendicitis. The incidence rate of 16.9 per 10,000 person-years in the ESRD cohort was higher than that in the control cohort (p = 0.003). The independent risk factors were atrial fibrillation (hazard ratio [HR], 2.08), severe liver disease (HR, 1.74), diabetes mellitus (HR, 1.58), and hemodialysis (HR, 1.74). Compared with the control cohort, subsequent perforation and mortality rates of acute appendicitis were also higher in the ESRD cohorts. There was no effect of dialysis modality on the patient outcomes. Conclusions: ESRD patients had a higher risk for acute appendicitis and poorer outcomes than non-dialysis populations. A careful examination of ESRD patients presenting with atypical abdominal pain to avoid misdiagnosis is extremely important to prevent delayed surgery.

AB - Background: Acute appendicitis in patients with end-stage renal disease (ESRD) poses a diagnostic challenge. Delayed surgery can contribute to higher morbidity and mortality rates. However, few studies have evaluated this disease among ESRD patients. Our study focused on the lack of data on the incidence and risk factors of acute appendicitis among ESRD patients and compared the outcomes in patients who underwent different dialysis modalities. Methods: This national survey was conducted between 1997 and 2005 and included ESRD patients identified from the Taiwan National Health Insurance database. The incidence rate of acute appendicitis in ESRD patients was compared with that in randomly selected age-, sex-, and Charlson comorbidity score-matched non-dialysis controls. A Cox regression hazard model was used to identify risk factors. Results: Among 59,781 incident ESRD patients, matched one-to-one with controls, there were 328 events of acute appendicitis. The incidence rate of 16.9 per 10,000 person-years in the ESRD cohort was higher than that in the control cohort (p = 0.003). The independent risk factors were atrial fibrillation (hazard ratio [HR], 2.08), severe liver disease (HR, 1.74), diabetes mellitus (HR, 1.58), and hemodialysis (HR, 1.74). Compared with the control cohort, subsequent perforation and mortality rates of acute appendicitis were also higher in the ESRD cohorts. There was no effect of dialysis modality on the patient outcomes. Conclusions: ESRD patients had a higher risk for acute appendicitis and poorer outcomes than non-dialysis populations. A careful examination of ESRD patients presenting with atypical abdominal pain to avoid misdiagnosis is extremely important to prevent delayed surgery.

KW - Acute appendicitis

KW - End-stage renal disease

KW - Epidemiology

KW - Mortality

KW - Renal replacement therapy

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