Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy

Hong Nerng Ho, Kuang Han Chao, Chun Kai Chen, Yu Shih Yang, Su Cheng Huang

研究成果: 雜誌貢獻文章

78 引文 斯高帕斯(Scopus)

摘要

Endometrial lymphocytes were studied at all stages throughout the menstrual cycle and early pregnancy by flow cytometry to examine different lymphocyte subpopulations and the expression of the T- and NK-cell activation markers. After pregnancy, CD8 + CD3 + lymphocytes were decreased in the decidua. In both endometrium and decidua, more T cells expressed CD69, CD71, HLA-DR, and CD38 antigens than in peripheral blood. After pregnancy, CD71 + CD3 + lymphocytes were further increased. CD25 + CD3 + lymphocytes decreased significantly in the endometrium and decidua of ectopic pregnancies, but not in the decidua of normal pregnancies. These findings indicate that T cells are regionally activated in the first trimester, and it may be the result of the stimulation by fetal antigens. NK cells were the most abundant cell type in the decidua, which expressed the phenotype CD16 CD56 + , and CD57 CD56 + . The proportion of activated decidual NK cells was increased in anembryonic pregnancies more than in normal pregnancies, although the total NK subpopulation was similar in both groups. This might result in increased NK cytotoxicity in anembryonic pregnancies. In conclusion, T cells are activated, but NK cytotoxicity is decreased in the decidua of early normal pregnancies. This might be important in the control of trophoblast growth and placental development.
原文英語
頁(從 - 到)130-136
頁數7
期刊Human Immunology
49
發行號2
DOIs
出版狀態已發佈 - 九月 1 1996
對外發佈Yes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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