Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression

Kai Wen Hsu, Rong Hong Hsieh, Kuo Hung Huang, Anna Fen Yau Li, Chin Wen Chi, Tzu Yin Wang, Min Jen Tseng, Kou Juey Wu, Tian-Shun Tsai

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91 引文 斯高帕斯(Scopus)

摘要

Gastric carcinoma is one of the most common malignancies and a lethal cancer in the world. Notch signaling and transcription factors STAT3 (signal transducer and activator of transcription 3) and Twist regulate tumor development and are critical regulators of gastric cancer progression. Herein, the relationship among Notch, STAT3 and Twist pathways in the control of gastric cancer progression was studied. We found that Twist and phosphorylated STAT3 levels were promoted by the activated Notch1 receptor in human stomach adenocarcinoma SC-M1, embryonic kidney HEK293 and erythroleukemia K562 cells. Notch1 signaling dramatically induced Twist promoter activity through a C promoter binding factor-1-independent manner and STAT3 phosphorylation.
原文英語
頁(從 - 到)1459-1467
頁數9
期刊Carcinogenesis
33
發行號8
DOIs
出版狀態已發佈 - 八月 2012

ASJC Scopus subject areas

  • Cancer Research

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