Activation of the NLRP3 and AIM2 inflammasomes in a mouse model of Schistosoma mansoni infection

T. T.W. Chen, P. C. Cheng, K. C. Chang, J. P. Cao, J. L. Feng, C. C. Chen, H. Y.P. Lam, S. Y. Peng

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Schistosomiasis is an inflammatory disease that occurs when schistosome species eggs are deposited in the liver, resulting in fibrosis and portal hypertension. Schistosomes can interact with host inflammasomes to elicit host immune responses, leading to mitochondrial damage, generation of high levels of reactive oxygen species ROS and activation of apoptosis during inflammation. This study aims to examine whether ROS and NF-κB p65 expression elicited other types of inflammasome activation in Schistosoma mansoni-infected mouse livers. We examine the relationship between inflammasome activation, mitochondrial damage and ROS production in mouse livers infected with S. Mansoni. We demonstrate a significant release of ROS and superoxides and increased NF-κB p65 in S. Mansoni-infected mouse livers. Moreover, activation of the NLRP3 and AIM2 inflammasomes was triggered by S. Mansoni infection. Stimulation of HuH-7 hepatocellular carcinoma cells with soluble egg antigen induced activation of the AIM2 inflammasome pathway. In this study, we demonstrate that S. Mansoni infection promotes both NLRP3 and AIM2 inflammasome activation.

原文英語
文章編號e72
期刊Journal of Helminthology
94
DOIs
出版狀態已發佈 - 一月 1 2020

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology

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    Chen, T. T. W., Cheng, P. C., Chang, K. C., Cao, J. P., Feng, J. L., Chen, C. C., Lam, H. Y. P., & Peng, S. Y. (2020). Activation of the NLRP3 and AIM2 inflammasomes in a mouse model of Schistosoma mansoni infection. Journal of Helminthology, 94, [e72]. https://doi.org/10.1017/S0022149X19000622