Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Ting Ting Yang, Cheng Kuei Chang, Chiung Wen Tsao, Ya Mei Hsu, Chao Tien Hsu, Juei Tang Cheng

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)

摘要

Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.
原文英語
頁(從 - 到)57-59
頁數3
期刊Neuroscience Letters
451
發行號1
DOIs
出版狀態已發佈 - 二月 13 2009
對外發佈Yes

ASJC Scopus subject areas

  • Neuroscience(all)

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