Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Ting Ting Yang, Cheng Kuei Chang, Chiung Wen Tsao, Ya Mei Hsu, Chao Tien Hsu, Juei Tang Cheng

研究成果: 雜誌貢獻文章

21 引文 (Scopus)

摘要

Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.
原文英語
頁(從 - 到)57-59
頁數3
期刊Neuroscience Letters
451
發行號1
DOIs
出版狀態已發佈 - 二月 13 2009
對外發佈Yes

指紋

Lipolysis
Cholinergic Agents
Adipose Tissue
Acetylcholine
Glucose
White Adipose Tissue
Muscarinic M3 Receptors
Muscarinic Receptors
Glycerol
Wistar Rats
Insulin

ASJC Scopus subject areas

  • Neuroscience(all)

引用此文

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats. / Yang, Ting Ting; Chang, Cheng Kuei; Tsao, Chiung Wen; Hsu, Ya Mei; Hsu, Chao Tien; Cheng, Juei Tang.

於: Neuroscience Letters, 卷 451, 編號 1, 13.02.2009, p. 57-59.

研究成果: 雜誌貢獻文章

Yang, Ting Ting ; Chang, Cheng Kuei ; Tsao, Chiung Wen ; Hsu, Ya Mei ; Hsu, Chao Tien ; Cheng, Juei Tang. / Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats. 於: Neuroscience Letters. 2009 ; 卷 451, 編號 1. 頁 57-59.
@article{1470a6ee197a4f42be4654489c84f1c6,
title = "Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats",
abstract = "Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.",
keywords = "Acetylcholine, Adipose, Glucose uptake, Lipolysis, Muscarinic receptor",
author = "Yang, {Ting Ting} and Chang, {Cheng Kuei} and Tsao, {Chiung Wen} and Hsu, {Ya Mei} and Hsu, {Chao Tien} and Cheng, {Juei Tang}",
year = "2009",
month = "2",
day = "13",
doi = "10.1016/j.neulet.2008.12.029",
language = "English",
volume = "451",
pages = "57--59",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

AU - Yang, Ting Ting

AU - Chang, Cheng Kuei

AU - Tsao, Chiung Wen

AU - Hsu, Ya Mei

AU - Hsu, Chao Tien

AU - Cheng, Juei Tang

PY - 2009/2/13

Y1 - 2009/2/13

N2 - Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

AB - Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC-PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue.

KW - Acetylcholine

KW - Adipose

KW - Glucose uptake

KW - Lipolysis

KW - Muscarinic receptor

UR - http://www.scopus.com/inward/record.url?scp=58649123092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58649123092&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2008.12.029

DO - 10.1016/j.neulet.2008.12.029

M3 - Article

VL - 451

SP - 57

EP - 59

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -