Activation of dopamine D2-like receptors attenuates pulmonary C-fiber hypersensitivity in rats

You Shuei Lin, Qihai Gu, Lu Yuan Lee

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

This study was performed to determine whether activation of dopamine D2-like receptors inhibits the hyperresponsiveness of pulmonary C fibers induced by inflammatory mediators such as prostaglandin E2 (PGE2). In anesthetized, open-chest rats, constant infusion of PGE2 (1.5-4.5 μg/kg per minute, 2 minutes) significantly enhanced the C-fiber response to capsaicin injection. At 20 minutes after pretreatment with quinpirole (3 mg/kg, intravenous), a D2-like receptor agonist, the hyperresponsiveness to capsaicin of the same C fibers induced by PGE2 infusion was markedly attenuated, and this inhibitory effect lasted for more than 90 minutes. The effect of quinpirole was dose dependent and was antagonized by pretreatment with domperidone (5 mg/kg, intravenous), a D2-like receptor antagonist, administrated 10 minutes before the quinpirole injection. In a separate series of experiments, C-fiber responses to injections of phenyl biguanide and lactic acid and to constant-pressure lung inflation were augmented by PGE2; these potentiating responses were also significantly reduced by quinpirole. Furthermore, the effect of quinpirole was equally effective in inhibiting the increase in excitability of pulmonary C fibers induced by alveolar hypercapnia or constant infusion of adenosine. In conclusion, these results clearly show that activation of the dopamine D2-like receptors attenuates the hyperresponsiveness of pulmonary C fibers to both chemical stimuli and lung inflation.

原文英語
頁(從 - 到)1096-1101
頁數6
期刊American Journal of Respiratory and Critical Care Medicine
167
發行號8
DOIs
出版狀態已發佈 - 四月 15 2003
對外發佈Yes

指紋

Unmyelinated Nerve Fibers
Dopamine D2 Receptors
Quinpirole
Hypersensitivity
Dinoprostone
Lung
Capsaicin
Economic Inflation
Injections
Domperidone
Hypercapnia
Adenosine
Lactic Acid
Thorax
Pressure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

引用此文

Activation of dopamine D2-like receptors attenuates pulmonary C-fiber hypersensitivity in rats. / Lin, You Shuei; Gu, Qihai; Lee, Lu Yuan.

於: American Journal of Respiratory and Critical Care Medicine, 卷 167, 編號 8, 15.04.2003, p. 1096-1101.

研究成果: 雜誌貢獻文章

@article{588ede43cb004febadeff7c05098f9d5,
title = "Activation of dopamine D2-like receptors attenuates pulmonary C-fiber hypersensitivity in rats",
abstract = "This study was performed to determine whether activation of dopamine D2-like receptors inhibits the hyperresponsiveness of pulmonary C fibers induced by inflammatory mediators such as prostaglandin E2 (PGE2). In anesthetized, open-chest rats, constant infusion of PGE2 (1.5-4.5 μg/kg per minute, 2 minutes) significantly enhanced the C-fiber response to capsaicin injection. At 20 minutes after pretreatment with quinpirole (3 mg/kg, intravenous), a D2-like receptor agonist, the hyperresponsiveness to capsaicin of the same C fibers induced by PGE2 infusion was markedly attenuated, and this inhibitory effect lasted for more than 90 minutes. The effect of quinpirole was dose dependent and was antagonized by pretreatment with domperidone (5 mg/kg, intravenous), a D2-like receptor antagonist, administrated 10 minutes before the quinpirole injection. In a separate series of experiments, C-fiber responses to injections of phenyl biguanide and lactic acid and to constant-pressure lung inflation were augmented by PGE2; these potentiating responses were also significantly reduced by quinpirole. Furthermore, the effect of quinpirole was equally effective in inhibiting the increase in excitability of pulmonary C fibers induced by alveolar hypercapnia or constant infusion of adenosine. In conclusion, these results clearly show that activation of the dopamine D2-like receptors attenuates the hyperresponsiveness of pulmonary C fibers to both chemical stimuli and lung inflation.",
keywords = "Inflammation mediators, Quinpirole, Respiratory hypersensitivity, Sensory",
author = "Lin, {You Shuei} and Qihai Gu and Lee, {Lu Yuan}",
year = "2003",
month = "4",
day = "15",
doi = "10.1164/rccm.200210-1171OC",
language = "English",
volume = "167",
pages = "1096--1101",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "8",

}

TY - JOUR

T1 - Activation of dopamine D2-like receptors attenuates pulmonary C-fiber hypersensitivity in rats

AU - Lin, You Shuei

AU - Gu, Qihai

AU - Lee, Lu Yuan

PY - 2003/4/15

Y1 - 2003/4/15

N2 - This study was performed to determine whether activation of dopamine D2-like receptors inhibits the hyperresponsiveness of pulmonary C fibers induced by inflammatory mediators such as prostaglandin E2 (PGE2). In anesthetized, open-chest rats, constant infusion of PGE2 (1.5-4.5 μg/kg per minute, 2 minutes) significantly enhanced the C-fiber response to capsaicin injection. At 20 minutes after pretreatment with quinpirole (3 mg/kg, intravenous), a D2-like receptor agonist, the hyperresponsiveness to capsaicin of the same C fibers induced by PGE2 infusion was markedly attenuated, and this inhibitory effect lasted for more than 90 minutes. The effect of quinpirole was dose dependent and was antagonized by pretreatment with domperidone (5 mg/kg, intravenous), a D2-like receptor antagonist, administrated 10 minutes before the quinpirole injection. In a separate series of experiments, C-fiber responses to injections of phenyl biguanide and lactic acid and to constant-pressure lung inflation were augmented by PGE2; these potentiating responses were also significantly reduced by quinpirole. Furthermore, the effect of quinpirole was equally effective in inhibiting the increase in excitability of pulmonary C fibers induced by alveolar hypercapnia or constant infusion of adenosine. In conclusion, these results clearly show that activation of the dopamine D2-like receptors attenuates the hyperresponsiveness of pulmonary C fibers to both chemical stimuli and lung inflation.

AB - This study was performed to determine whether activation of dopamine D2-like receptors inhibits the hyperresponsiveness of pulmonary C fibers induced by inflammatory mediators such as prostaglandin E2 (PGE2). In anesthetized, open-chest rats, constant infusion of PGE2 (1.5-4.5 μg/kg per minute, 2 minutes) significantly enhanced the C-fiber response to capsaicin injection. At 20 minutes after pretreatment with quinpirole (3 mg/kg, intravenous), a D2-like receptor agonist, the hyperresponsiveness to capsaicin of the same C fibers induced by PGE2 infusion was markedly attenuated, and this inhibitory effect lasted for more than 90 minutes. The effect of quinpirole was dose dependent and was antagonized by pretreatment with domperidone (5 mg/kg, intravenous), a D2-like receptor antagonist, administrated 10 minutes before the quinpirole injection. In a separate series of experiments, C-fiber responses to injections of phenyl biguanide and lactic acid and to constant-pressure lung inflation were augmented by PGE2; these potentiating responses were also significantly reduced by quinpirole. Furthermore, the effect of quinpirole was equally effective in inhibiting the increase in excitability of pulmonary C fibers induced by alveolar hypercapnia or constant infusion of adenosine. In conclusion, these results clearly show that activation of the dopamine D2-like receptors attenuates the hyperresponsiveness of pulmonary C fibers to both chemical stimuli and lung inflation.

KW - Inflammation mediators

KW - Quinpirole

KW - Respiratory hypersensitivity

KW - Sensory

UR - http://www.scopus.com/inward/record.url?scp=0037447326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037447326&partnerID=8YFLogxK

U2 - 10.1164/rccm.200210-1171OC

DO - 10.1164/rccm.200210-1171OC

M3 - Article

C2 - 12531778

AN - SCOPUS:0037447326

VL - 167

SP - 1096

EP - 1101

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 8

ER -