Action of Reverse T3 on Cancer Cells

Hung Yun Lin, Heng Yuan Tang, Matthew Leinung, Shaker A. Mousa, Aleck Hercbergs, Paul J. Davis

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05–0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.
原文英語
期刊Endocrine Research
DOIs
出版狀態已發佈 - 一月 1 2019

指紋

Integrins
Thyronines
Thyroid Hormone Receptors
Neoplasms
Glioblastoma
Thyroxine
Thyroid Hormones
Cell Proliferation
Cell Membrane
Breast Neoplasms
Growth
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology

引用此文

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A., & Davis, P. J. (2019). Action of Reverse T3 on Cancer Cells. Endocrine Research. https://doi.org/10.1080/07435800.2019.1600536

Action of Reverse T3 on Cancer Cells. / Lin, Hung Yun; Tang, Heng Yuan; Leinung, Matthew; Mousa, Shaker A.; Hercbergs, Aleck; Davis, Paul J.

於: Endocrine Research, 01.01.2019.

研究成果: 雜誌貢獻文章

Lin, HY, Tang, HY, Leinung, M, Mousa, SA, Hercbergs, A & Davis, PJ 2019, 'Action of Reverse T3 on Cancer Cells', Endocrine Research. https://doi.org/10.1080/07435800.2019.1600536
Lin HY, Tang HY, Leinung M, Mousa SA, Hercbergs A, Davis PJ. Action of Reverse T3 on Cancer Cells. Endocrine Research. 2019 1月 1. https://doi.org/10.1080/07435800.2019.1600536
Lin, Hung Yun ; Tang, Heng Yuan ; Leinung, Matthew ; Mousa, Shaker A. ; Hercbergs, Aleck ; Davis, Paul J. / Action of Reverse T3 on Cancer Cells. 於: Endocrine Research. 2019.
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