ACEI and ARB did not reduce the incidence of dementia in patients with atrial fibrillation: A nationwide cohort study

Min Tsun Liao, Lian Yu Lin, Yao Hsu Yang, Tin Tse Lin, Jiunn Lee Lin, Pau Chung Chen, Chia Ti Tsai

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Purpose: Atrial fibrillation (AF) is associated with increased risk of thromboembolism, and is also a predisposing factor to dementia. Our investigation was a retrospective observational study to evaluate whether the usage of angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) could reduce the incidence of dementia in patients with AF. Methods: A total of 5221 patients over 20 years of age who had a history of AF as noted in ambulatory and inpatient claims data were enrolled from the National Health Insurance Research Database of Taiwan in 1997 and 1998. Patients with ACEI or ARB were designated as group 1 (4343 patients), and patients without ACEI or ARB were designated as group 2 (878 patients). Results: During a follow-up of 5.90-3.39 years, 135 patients of group 1 (3.1%) and 25 of group 2 (2.8%) developed new-onset dementia. Group 1 and group 2 had similar proportions of new-onset dementia (p = 0.75). The Kaplan-Meier curve demonstrated that patients with ACEI or ARB were not associated with a lower incidence of dementia during the follow-up period (log rank p = 0.91). Cox-regression analysis also showed that usage of ACEI or ARB was not associated with a lower risk of new-onset dementia after adjustment for gender and comorbidities. (Hazard ratio = 0.942, 95% confidence interval 0.589-1.506, and p = 0.80). Conclusions: ACEI or ARB may be ineffective in reducing the incidence of dementia in patients with AF.
原文英語
頁(從 - 到)323-327
頁數5
期刊Acta Cardiologica Sinica
29
發行號4
出版狀態已發佈 - 七月 1 2013
對外發佈Yes

Keywords

  • Angiotensin II receptor blocker
  • Angiotensin-converting-enzyme inhibitor
  • Atrial fibrillation
  • Dementia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Liao, M. T., Lin, L. Y., Yang, Y. H., Lin, T. T., Lin, J. L., Chen, P. C., & Tsai, C. T. (2013). ACEI and ARB did not reduce the incidence of dementia in patients with atrial fibrillation: A nationwide cohort study. Acta Cardiologica Sinica, 29(4), 323-327.