Accumulation of chromium and nickel metals in lung tumors from lung cancer patients in Taiwan

Chung Yih Kuo, Ruey Hong Wong, Jia Yi Lin, Ji Ching Lai, Huei Lee

研究成果: 雜誌貢獻文章同行評審

54 引文 斯高帕斯(Scopus)

摘要

Metallic carcinogenicity is generally thought to generate of free radicals, and thus some metals were reported to play a role in lung tumorigenesis. In order to verify the role of heavy metals in the development of Taiwanese lung cancer, a case-control study was conducted to compare heavy metal contents between 60 tumor and 42 normal lung tissues surgically resected from lung cancer and noncancer patients. The tissue concentration of heavy metals, including cadmium (Cd), chromium (Cr), cobalt (Co), lead (Pb), and nickel (Ni), was measured using by atomic absorption spectrometry (AAS). Our results indicated that Cr and Ni contents in lung tumors of lung cancer patients were significantly higher than those in normal lung tissue of noncancer controls, but Co content was markedly lower in lung tumors. Additionally, Pb content in lung tumors was associated with nodal involvement, and Co amounts in squamous-cell carcinomas were relatively higher than those in adenocarcinomas. Data suggest that accumulation of Cr and Ni in lung tumors may play a role, at least in part, in the development of lung cancer in Taiwan. Copyright
原文英語
頁(從 - 到)1337-1344
頁數8
期刊Journal of Toxicology and Environmental Health - Part A: Current Issues
69
發行號14
DOIs
出版狀態已發佈 - 2006
對外發佈

ASJC Scopus subject areas

  • 毒理學
  • 健康、毒理學和誘變

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