Absorption and emission spectral shifts of rose bengal associated with DMPC liposomes

Cheng Chung Chang, Yu Tsai Yang, Jen Chang Yang, Hong Da Wu, Tsuimin Tsai

研究成果: 雜誌貢獻文章

61 引文 (Scopus)

摘要

Rose bengal is a water-soluble xanthene dye that is currently used in ophthalmology for the diagnosis of dry eyes. Although the dye is also a potential photosensitizer for photodynamic therapy of tumors, owing to insufficient lipophilicity and tumor accumulation, the clinical application of rose bengal in photodynamic therapy has been hampered. Liposomal encapsulation was seen as a promising approach to overcome these disadvantages, to which end, the spectral properties of the dye in the presence of materials for liposome preparation were studied. The presence of phospholipid influenced the spectral properties of the dye, probably due to the establishment of an equilibrium between monomeric and dimeric forms of the dye, since the photophysical properties of rose bengal depend strongly on its environment. The liposomal encapsulation of the dye generates stronger emission than the free form of the colorant; increased lipid:dye ratio further enhances this emission.
原文英語
頁(從 - 到)170-175
頁數6
期刊Dyes and Pigments
79
發行號2
DOIs
出版狀態已發佈 - 十一月 2008

指紋

Dimyristoylphosphatidylcholine
Rose Bengal
Liposomes
Coloring Agents
Dyes
Photodynamic therapy
Encapsulation
Tumors
Xanthenes
Ophthalmology
Photosensitizing Agents
Photosensitizers
Phospholipids
Lipids
Water

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Process Chemistry and Technology

引用此文

Absorption and emission spectral shifts of rose bengal associated with DMPC liposomes. / Chang, Cheng Chung; Yang, Yu Tsai; Yang, Jen Chang; Wu, Hong Da; Tsai, Tsuimin.

於: Dyes and Pigments, 卷 79, 編號 2, 11.2008, p. 170-175.

研究成果: 雜誌貢獻文章

Chang, Cheng Chung ; Yang, Yu Tsai ; Yang, Jen Chang ; Wu, Hong Da ; Tsai, Tsuimin. / Absorption and emission spectral shifts of rose bengal associated with DMPC liposomes. 於: Dyes and Pigments. 2008 ; 卷 79, 編號 2. 頁 170-175.
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abstract = "Rose bengal is a water-soluble xanthene dye that is currently used in ophthalmology for the diagnosis of dry eyes. Although the dye is also a potential photosensitizer for photodynamic therapy of tumors, owing to insufficient lipophilicity and tumor accumulation, the clinical application of rose bengal in photodynamic therapy has been hampered. Liposomal encapsulation was seen as a promising approach to overcome these disadvantages, to which end, the spectral properties of the dye in the presence of materials for liposome preparation were studied. The presence of phospholipid influenced the spectral properties of the dye, probably due to the establishment of an equilibrium between monomeric and dimeric forms of the dye, since the photophysical properties of rose bengal depend strongly on its environment. The liposomal encapsulation of the dye generates stronger emission than the free form of the colorant; increased lipid:dye ratio further enhances this emission.",
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AB - Rose bengal is a water-soluble xanthene dye that is currently used in ophthalmology for the diagnosis of dry eyes. Although the dye is also a potential photosensitizer for photodynamic therapy of tumors, owing to insufficient lipophilicity and tumor accumulation, the clinical application of rose bengal in photodynamic therapy has been hampered. Liposomal encapsulation was seen as a promising approach to overcome these disadvantages, to which end, the spectral properties of the dye in the presence of materials for liposome preparation were studied. The presence of phospholipid influenced the spectral properties of the dye, probably due to the establishment of an equilibrium between monomeric and dimeric forms of the dye, since the photophysical properties of rose bengal depend strongly on its environment. The liposomal encapsulation of the dye generates stronger emission than the free form of the colorant; increased lipid:dye ratio further enhances this emission.

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