Abnormal preconception oral glucose tolerance test predicts an unfavorable pregnancy outcome after an in vitro fertilization cycle

Hsiao Jui Wei, Robert Young, I. Li Kuo, Chian Mey Liaw, Han-Sun Chiang, Ching Ying Yeh

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Objective: To determine the relationship between the 75-g oral glucose tolerance test and pregnancy outcome after women's first IVF cycle. Design: Prospective study. Setting: Infertility center at a private tertiary hospital in Taiwan. Patient(s): All 280 patients who went through their initial IVF cycle at the hospital between January 2004 and April 2005 were included in the study. Intervention(s): Two hundred eighty patients underwent an oral glucose tolerance test before entering an IVF cycle; all pregnancy outcomes and pregnancy complications were recorded. Main Outcome Measure(s): The relationships between glycemic parameters and insulin resistance and IVF pregnancy outcome were determined. Linear regression between birth weight and levels of preconception fasting insulin, 2-hour glucose, and 2-hour insulin was performed. Result(s): One hundred twenty patients conceived after their initial IVF cycle. Twenty-five of 89 ongoing pregnancies had various complications. The most common pregnancy complication was preterm birth (n = 11). These patients had higher body mass index (23.46 vs. 20.97 kg/m 2); higher fasting glucose (107.36 vs. 95.14 mg/dL), fasting insulin (10.55 vs. 6.20 μIU/mL), and 2-hour glucose (120.55 vs. 99.97 mg/dL) levels; and higher homeostatic model assessment of insulin resistance (3.43 vs. 1.45) than did patients with full-term pregnancies. Linear regression between birth weight and the fasting glucose level and between birth weight and the homeostatic model assessment of insulin resistance had positive correlations. Conclusion(s): Before proceeding with IVF, preconception oral glucose tolerance testing is suggested, especially in patients with higher body mass index, to help identify groups who are at high risk for preterm birth.
原文英語
頁(從 - 到)613-618
頁數6
期刊Fertility and Sterility
90
發行號3
DOIs
出版狀態已發佈 - 九月 2008

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

指紋 深入研究「Abnormal preconception oral glucose tolerance test predicts an unfavorable pregnancy outcome after an in vitro fertilization cycle」主題。共同形成了獨特的指紋。

  • 引用此