Abnormal histone acetylase and deacetylase expression and function in lung inflammation

I. M. Adcock, K. Y. Lee

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

摘要

Post-translational modifications in DNA and histone proteins are heritable changes that are not coded for in the DNA sequence itself but play an important role in the control of gene expression. These modifications include histone acetylation, methylation, ubiquitination, sumoylation and phosphorylation. These changes are not only critical for generating diversity of cell types during mammalian development, but are also important for maintaining the stability and integrity of the expression profiles of different cell types. Until recently, the study of human disease has focused on genetic mechanisms rather than on non-coding events. However, it is becoming increasingly clear that altered patterns of histone modifications can lead to several major pathologies. This review focuses on histone acetylation and its role in inflammatory gene expression. Interestingly, the expression and activity of enzymes that regulate this modification have been reported to be abnormal in the airways of patients with respiratory disease. Histone modifications, despite being heritable and stably maintained, are also potentially reversible and there is scope for the development of "epigenetic therapies" for disease.

原文英語
頁(從 - 到)311-321
頁數11
期刊Inflammation Research
55
發行號8
DOIs
出版狀態已發佈 - 八月 2006
對外發佈Yes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

指紋 深入研究「Abnormal histone acetylase and deacetylase expression and function in lung inflammation」主題。共同形成了獨特的指紋。

  • 引用此