A young female with Spitzer-Weinstein syndrome diagnosed by thiazide test

Cheng Hao Weng, Jen Wei Cheng, Chen Chieh Hung, Mai Szu Wu, Chih Wei Yang, Chiz Tzung Chang

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)


Spitzer-Weinstein syndrome is a rare disorder characterized by thiazide responsive hyperkalemia and normal anion gap metabolic acidosis, similar to Gordon syndrome. The hyperfunction of thiazide-sensitive Na+-Cl- cotransporter (TSC) is the main pathophysiological mechanism. We presented a 19-year-old female with short stature, normal blood pressure, persistently elevated serum potassium, and metabolic acidosis. The diagnosis of Spitzer-Weinstein Syndrome was made by clinical pictures and thiazide test. After taking 4 mg hydrochlorothiazide, her daily urine potassium excretion increased from 18.1 mmol to 41.8 mmol, urine pH decreased from 7.32 to 6.50, and urinary net charge decreased from 65.7 to 54.4. This patient then took hydrochlorothiazide 4 mg daily. The persistent hyperkalemia and metabolic acidosis were corrected. Thiazide, a powerful inhibitor of TSC, proved to be a useful tool for the diagnosis and treatment of Spitzer-Weinstein syndrome.

頁(從 - 到)239-241
期刊Renal Failure
出版狀態已發佈 - 2月 2007

ASJC Scopus subject areas

  • 腎臟病學


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