A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chien Tien Chen, Yogesh S. Munot, Santosh B. Salunke, Yi Ching Wang, Ruo Kai Lin, Chun Cheng Lin, Chia Chun Chen, Y. Hsin Liu

研究成果: 雜誌貢獻文章

44 引文 (Scopus)

摘要

A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.

原文英語
頁(從 - 到)527-540
頁數14
期刊Advanced Functional Materials
18
發行號4
DOIs
出版狀態已發佈 - 二月 22 2008
對外發佈Yes

指紋

Galactosides
Fluorescent Dyes
lungs
cancer
Cells
Nanoparticles
mitosis
nanoparticles
Drug Carriers
probes
apoptosis
Cell death
Anchors
serums
drugs
Nuclear magnetic resonance
chemistry
Apoptosis
membranes
Membranes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Science(all)
  • Condensed Matter Physics
  • Physics and Astronomy (miscellaneous)

引用此文

A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells. / Chen, Chien Tien; Munot, Yogesh S.; Salunke, Santosh B.; Wang, Yi Ching; Lin, Ruo Kai; Lin, Chun Cheng; Chen, Chia Chun; Liu, Y. Hsin.

於: Advanced Functional Materials, 卷 18, 編號 4, 22.02.2008, p. 527-540.

研究成果: 雜誌貢獻文章

Chen, Chien Tien ; Munot, Yogesh S. ; Salunke, Santosh B. ; Wang, Yi Ching ; Lin, Ruo Kai ; Lin, Chun Cheng ; Chen, Chia Chun ; Liu, Y. Hsin. / A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells. 於: Advanced Functional Materials. 2008 ; 卷 18, 編號 4. 頁 527-540.
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abstract = "A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.",
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AU - Salunke, Santosh B.

AU - Wang, Yi Ching

AU - Lin, Ruo Kai

AU - Lin, Chun Cheng

AU - Chen, Chia Chun

AU - Liu, Y. Hsin

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