A substance isolated from cornus offlcinalis enhances the motility of human sperm

Hellen Jeng, Chao Mei Wu, Shuen Jiing Su, Wen Chang Chang

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

The effects of a Chinese herb, Cornus officinalis, on the motility of human sperm was studied. An aqueous extract was prepared from the dried fruits of the herb and used in this study. The crude extract at a final concentration of 0.5 (ig/|J.l in phosphate buffered saline (pH 7.4) increased sperm motility from 25.8 ±7.7% to 42.8 ±10.3% (i.e. 68% increase, n = 7), as determined by the computer-aided-sperm-analysis (CASA) method. The crude extract was fractionated by high-performance liquid chromatography (HPLC) into four fractions: Cl, C2, C3 and C4. Their effects on sperm motility were further studied by CASA. Only the C4 fraction showed substantial stimulatory effects on sperm motility. At a concentration of 5 ng/u.1, C4 increased the sperm motility from 15.7 ±3.8% to 34.5 ±6.4% (i.e. 120% increase, n = 6) by CASA and from 14.9 + 4.3 to 28.5 ±8.1 (i.e. 91% increase, n = 8) by transmembrane migration ratio (TMMR) method. This result suggests that C4 is the active component in Comus officinalis that enhances sperm motility.
原文英語
頁(從 - 到)301-306
頁數6
期刊American Journal of Chinese Medicine
25
發行號3-4
出版狀態已發佈 - 1997
對外發佈

ASJC Scopus subject areas

  • 補充和替代醫學

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