A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy

Qunzhou Zhang, Shihong Shi, Yun Yen, Jimmy Brown, Joseph Quoc Ta, Anh D. Le

研究成果: 雜誌貢獻文章

170 引文 斯高帕斯(Scopus)

摘要

The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133- counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.

原文英語
頁(從 - 到)151-160
頁數10
期刊Cancer Letters
289
發行號2
DOIs
出版狀態已發佈 - 三月 28 2010
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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