A Structured–Activity Relationship Study of Batracylin Analogues

Yilin Luo, Yun Feng Ren, Ting Chao Chou, Allan Y. Chen, Chiang Yu, Leroy-Fong Liu, C. C. Cheng

研究成果: 雜誌貢獻文章同行評審

27 引文 斯高帕斯(Scopus)

摘要

A number of isoindolo[l ,2- b]quinazolines and some benzo[4,5]isoquinolino[l,2- b]quinazolines as structural modification analogues of the antitumor compound batracylin were synthesized and evaluated against HL-60 cell growth and in topoisomerase II-mediated DNA cleavage assays. Of the compounds studied, 10,12-dihydro-7,8-methy lenedioxyisoindolo[ 1,2- b] quinazolin-12(10 H)-one 1d, 2-amino-10,12-dihydroisoindolo[l ,2- b]quinazolin- 12(10 H)-one 1p, and 2-amino-7,8-methylenedioxy-10,12-dihydroisoindolo[l ,2- b]quinazolin-12(10 H)-one 1ab exhibited good inhibitory activities against HL-60 cell lines as well as induction of topo II-mediated DNA cleavage activities.

原文英語
頁(從 - 到)918-923
頁數6
期刊Pharmaceutical Research
10
發行號6
DOIs
出版狀態已發佈 - 1993
對外發佈Yes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Organic Chemistry
  • Pharmacology (medical)
  • Pharmaceutical Science
  • Pharmacology
  • Chemistry(all)

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